Z
Zhihua Xie
Researcher at Sanford-Burnham Institute for Medical Research
Publications - 23
Citations - 9363
Zhihua Xie is an academic researcher from Sanford-Burnham Institute for Medical Research. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 21, co-authored 22 publications receiving 9164 citations. Previous affiliations of Zhihua Xie include University of California, San Diego & University of Technology of Compiègne.
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Journal ArticleDOI
Bax directly induces release of cytochrome c from isolated mitochondria
Juliane M. Jürgensmeier,Zhihua Xie,Quinn Deveraux,Lisa M. Ellerby,Dale E. Bredesen,John C. Reed +5 more
TL;DR: It is shown that addition of submicromolar amounts of recombinant Bax protein to isolated mitochondria can induce cytochrome c (Cyt c) release, whereas a peptide representing the Bax BH3 domain was inactive, implying that Bax uses an alternative mechanism for triggering release of Cyt c from mitochondria.
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Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis
Isabel Marzo,Catherine Brenner,Naoufal Zamzami,Juliane M. Jürgensmeier,Santos A. Susin,Helena L. A. Vieira,Marie Christine Prévost,Zhihua Xie,Shigemi Matsuyama,John C. Reed,Guido Kroemer +10 more
TL;DR: The proapoptotic molecule Bax and the constitutive mitochondrial protein ANT cooperate within the PTPC to increase mitochondrial membrane permeability and to trigger cell death.
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The permeability transition pore complex: a target for apoptosis regulation by caspases and bcl-2-related proteins.
Isabel Marzo,Catherine Brenner,Naoufal Zamzami,Santos A. Susin,Gisela Beutner,Dieter Brdiczka,René Rémy,Zhihua Xie,John C. Reed,Guido Kroemer +9 more
TL;DR: It is shown that PT pore complexes reconstituted in liposomes exhibit a functional behavior comparable with that of the naturalPT pore present in intact mitochondria.
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Cytochrome c Release and Apoptosis Induced by Mitochondrial Targeting of Nuclear Orphan Receptor TR3
Hui Li,Siva Kumar Kolluri,Jian Gu,Marcia I. Dawson,Xihua Cao,Peter D. Hobbs,Bingzhen Lin,Guo-quen Chen,Jiang-song Lu,Feng Lin,Zhihua Xie,Joseph A. Fontana,John C. Reed,Xiao-kun Zhang +13 more
TL;DR: In this paper, the authors reveal a mechanism by which a nuclear transcription factor translocates to mitochondria to initiate apoptosis, but not its DNA binding and transactivation, is essential for its proapoptotic effect.
Journal Article
Channel formation by anti-apoptotic protein, BCL-2
Sharon L. Schendel,Zhihua Xie,Myrta Otlatt Montal,Shigemi Matsuyama,Mauricio Montal,John C. Reed +5 more
TL;DR: In this paper, the pore-forming domains of Bcl-2 proteins were compared to those of diphtheria toxin and colicins, suggesting a novel function for this anti-apoptotic protein.