François Sanschagrin

TL;DR: Four genes from four prophage clusters and one genomic island were demonstrated to strongly impact on competitiveness in the chronic rat lung infection model; this strongly indicates that enhanced in vivo competitiveness is a major driver for maintenance and diversifying selection of these genomicProphage genes.

TL;DR: Basic knowledge of sigma and ECF proteins was reviewed with particular emphasis on their role in P. aeruginosa global gene regulation to provide new means to prevent infection, new targets for antimicrobial therapy, as well as new insights into the infection process.

TL;DR: Genotypic resistance analyses of ETEC isolates from pigs indicate that many of the antibiotic resistance genes behind phenotypesic resistance are not static but, rather, are in a state of flux driven by various selection forces such as the use of specific antimicrobials.

TL;DR: Several attempts made to develop novel inhibitors of this pathway are discussed in this paper, including 4-Thiazolidinone compounds were designed as MurB inhibitors and many phosphinic acid derivatives and substrate analogues were identified as inhibitors of the MurC to MurF amino acid ligases.

TL;DR: A multiplex polymerase chain reaction-based signature-tagged mutagenesis (STM) for high-throughput screening of a collection of 7968 P. aeruginosa mutants in a rat model of chronic respiratory infection revealed 36 STM mutants defective in protease, twitching motility, swimming and swarming.