G
Gee W. Lau
Researcher at University of Illinois at Urbana–Champaign
Publications - 89
Citations - 5318
Gee W. Lau is an academic researcher from University of Illinois at Urbana–Champaign. The author has contributed to research in topics: Pseudomonas aeruginosa & Virulence. The author has an hindex of 34, co-authored 81 publications receiving 4739 citations. Previous affiliations of Gee W. Lau include Purdue University & Urbana University.
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Journal ArticleDOI
The role of pyocyanin in Pseudomonas aeruginosa infection
TL;DR: This review briefly highlights recent advances that might clarify the role of PCN in P. aeruginosa pathogenesis.
Journal ArticleDOI
Plants and animals share functionally common bacterial virulence factors.
Laurence G. Rahme,Frederick M. Ausubel,Hui Cao,Eliana Drenkard,Boyan C. Goumnerov,Gee W. Lau,Mahajan-Miklos Shalina,Julia M. Plotnikova,Man-Wah Tan,Tsongalis John,Cynthia L. Walendziewicz,Ronald G. Tompkins +11 more
TL;DR: This work has developed model systems that use plants and nematodes as adjuncts to mammalian models to help elucidate the molecular basis of P. aeruginosa pathogenesis.
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Pseudomonas aeruginosa Pyocyanin Is Critical for Lung Infection in Mice
TL;DR: Pseudomonas aeruginosa secretes copious amounts of the redox-active phenazine, pyocyanin (PCN), during cystic fibrosis lung infection, which mediates tissue damage and necrosis during lung infection.
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A functional genomic analysis of type 3 Streptococcus pneumoniae virulence.
Gee W. Lau,Sauli J Haataja,Michael A. Lonetto,Sarah E. Kensit,Andrea Marra,Alexander P. Bryant,Damien McDevitt,Donald A. Morrison,David W. Holden +8 more
TL;DR: Five strains mutated in genes involved in gene regulation, cation transport or stress tolerance were shown to be highly attenuated when tested individually in a murine respiratory tract infection model, suggesting that induction of competence for genetic transformation has a role in virulence.
Journal ArticleDOI
Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions
Sang Sun Yoon,Ray D. Coakley,Gee W. Lau,Sergei V. Lymar,Benjamin Gaston,Benjamin Gaston,Ahmet C. Karabulut,Robert F. Hennigan,Sung-Hei Hwang,Garry R. Buettner,Michael J. Schurr,Joel E. Mortensen,Jane L. Burns,David P. Speert,Richard C. Boucher,Daniel J. Hassett +15 more
TL;DR: Show that mucoid bacteria perish during anaerobic exposure to 15 mM nitrite (NO2) at pH 6.5, which mimics CF airway mucus, and selective killing by HNO2 may provide novel insights into the important clinical goal of eradicatingMucoid P. aeruginosa from the CF airways.