F
François Trottein
Researcher at Pasteur Institute
Publications - 139
Citations - 9257
François Trottein is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Immune system & Inflammation. The author has an hindex of 49, co-authored 122 publications receiving 8380 citations. Previous affiliations of François Trottein include French Institute of Health and Medical Research & university of lille.
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Journal ArticleDOI
Identification of an IL-17–producing NK1.1neg iNKT cell population involved in airway neutrophilia
Marie-Laure Michel,Alexandre C. Keller,Christophe Paget,Christophe Paget,Masakazu Fujio,François Trottein,François Trottein,Paul B. Savage,Chi-Huey Wong,Elke Schneider,Michel Dy,Maria Leite-de-Moraes +11 more
TL;DR: This study identifies a particular set of iNKT cells that lack the NK1.1neg marker and represents a new population of IL-17–producing cells that can contribute to neutrophil recruitment through preferential IL- 17 secretion.
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Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway
Philippe Delerive,Françoise Martin-Nizard,Giulia Chinetti,François Trottein,Jean-Charles Fruchart,Jamila Najib,Patrick Duriez,Bart Staels +7 more
TL;DR: Data indicate that both PPARalpha and PPARgamma are expressed in human vascular endothelial cells and that PPAR activators inhibit thrombin-induced ET-1 biosynthesis, indicating a novel role for PPARs in vascular endothelium function.
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Immunoreactivity in mammals of two typical plant glyco-epitopes, core α(1,3)-fucose and core xylose
Muriel Bardor,Christelle Faveeuw,Anne-Catherine Fitchette,Danièle Gilbert,Ludovic Galas,François Trottein,Loïc Faye,Patrice Lerouge +7 more
TL;DR: It is demonstrated that about 50% of nonallergic blood donors contains in their sera Abs specific for core xylose, whereas 25% have Abs against core alpha(1,3)-fucose, and the presence of such Abs might introduce some limitations to the use of plant-derived biopharmaceutical glycoproteins, such as an accelerated clearance during human therapy.
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Role of the Parasite-Derived Prostaglandin D2 in the Inhibition of Epidermal Langerhans Cell Migration during Schistosomiasis Infection
Véronique Angeli,Christelle Faveeuw,Olivier Roye,Josette Fontaine,Elisabeth Teissier,André Capron,Isabelle Wolowczuk,Monique Capron,François Trottein +8 more
TL;DR: It is proposed that the inhibition of LC migration could represent an additional stratagem for the schistosomes to escape the host immune system and that PGD2 may play a key role in the control of cutaneous immune responses.
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Activation of Invariant NKT Cells by Toll-like Receptor 9-Stimulated Dendritic Cells Requires Type I Interferon and Charged Glycosphingolipids
Christophe Paget,Christophe Paget,Thierry Mallevaey,Thierry Mallevaey,Anneliese O. Speak,David Torres,David Torres,Josette Fontaine,Josette Fontaine,Kathleen C. F. Sheehan,Monique Capron,Monique Capron,Bernhard Ryffel,Christelle Faveeuw,Christelle Faveeuw,Maria Leite de Moraes,Frances M. Platt,François Trottein,François Trottein +18 more
TL;DR: iNKT cell activation in response to TLR9 stimulation required combined synthesis of type I interferon and de novo production of charged beta-linked glycosphingolipid(s) by DCs, which underline the role of TLR 9 in iN KT cell activation and might have relevance to infectious diseases and cancer.