Françoise Bressolle

TL;DR: This manuscript is intended to provide guiding principles for the evaluation of a method's overall performance, including sampling procedure, sample preparation, chromatographic separation, detection and data evaluation, and models used for analytical calibration curves are explained in term of validity and limitations.

TL;DR: There has been a continuous search for biological and pharmacological strategies to protect the renal function and thus permit the administration of high quantities of the drug; these strategies include modification of administration modes, development of new galenic forms, and the use of chemoprotectors, among others.

TL;DR: The basis for the liquid chromatographic and capillary electrophoretic resolution of drug enantiomers and the factors affecting their enantiomeric separation are described.

TL;DR: A method based on the measurement in blood samples of the sTfR/serum protein ratio to determine if the observed values of this marker are related to rHuEpo abuse is proposed.

TL;DR: A specific and sensitive liquid chromatography-electrospray ionization mass spectrometry method was described for the simultaneous determination of carbamazepine, oxcarbazepine and eight of their metabolites in human plasma and found suitable for the analysis of plasma samples collected during therapeutic drug monitoring of patients treated with CBZ or OXCBZ.