F
Françoise Robert
Researcher at French Institute of Health and Medical Research
Publications - 41
Citations - 1874
Françoise Robert is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Nervous system & Receptor. The author has an hindex of 19, co-authored 41 publications receiving 1826 citations. Previous affiliations of Françoise Robert include University of Liège.
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Journal ArticleDOI
Steroid hormones and neurosteroids in normal and pathological aging of the nervous system
Martin Schumacher,Sébastien Weill-Engerer,Philippe Liere,Françoise Robert,Robin J.M. Franklin,Luis M. Garcia-Segura,Jeremy J. Lambert,Willy Mayo,Roberto Cosimo Melcangi,Árpád Párducz,Ueli Suter,Claude Carelli,Etienne-Emile Baulieu,Yvette Akwa +13 more
TL;DR: In Alzheimer's patients, there was a general trend toward lower levels of neurosteroids in different brain regions, and neurosteroid levels were negatively correlated with two biochemical markers of Alzheimer's disease, the phosphorylated tau protein and the beta-amyloid peptides.
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Local synthesis and dual actions of progesterone in the nervous system: neuroprotection and myelination
Michael Schumacher,Rachida Guennoun,Françoise Robert,Claude Carelli,Nathalie Gago,Abdel M. Ghoumari,Maria Claudia Gonzalez Deniselle,Susana L. González,C. Ibanez,Florencia Labombarda,Héctor Coirini,Etienne-Emile Baulieu,Alejandro F. De Nicola +12 more
TL;DR: Local synthesis of PROG in the brain and the neuroprotective and promyelinating effects of this neurosteroid offer interesting therapeutic possibilities for the prevention and treatment of neurodegenerative diseases, for accelerating regenerative processes and for preserving cognitive functions during aging.
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Steroid synthesis and metabolism in the nervous system: Trophic and protective effects
Michael Schumacher,Yvette Akwa,Rachida Guennoun,Françoise Robert,Florencia Labombarda,Frank Desarnaud,P. Robel,De Nicola Af,Etienne-Emile Baulieu +8 more
TL;DR: The modulation of neurostransmitter receptors is involved in the psychopharmacological effects of steroids and allows to explain their anticonvulsant, anxiolytic, antidepressive and sedative effects as well as their influence on memory.
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Novel perspectives for progesterone in hormone replacement therapy, with special reference to the nervous system.
Michael Schumacher,Rachida Guennoun,Abdel M. Ghoumari,Charbel Massaad,Françoise Robert,Martine El-Etr,Yvette Akwa,Krzysztof Rajkowski,Etienne-Emile Baulieu +8 more
TL;DR: The utility and safety of postmenopausal hormone replacement therapy has recently been put into question by large clinical trials, and the recognition that progesterone is synthesized by neurons and glial cells requires a reevaluation of hormonal aging.
Journal ArticleDOI
Progesterone synthesis and myelin formation in peripheral nerves
Michael Schumacher,Rachida Guennoun,Gilles Mercier,Franck Desarnaud,Pascale N. Lacor,Jesus Benavides,Badia Ferzaz,Françoise Robert,Etienne-Emile Baulieu +8 more
TL;DR: It has been proposed that progesterone may indirectly regulate myelin formation by influencing gene expression in neurons as well as activating the expression of genes coding for transcription factors and/or for myelin proteins.