F
Frank R. de Gruijl
Researcher at Leiden University Medical Center
Publications - 139
Citations - 6707
Frank R. de Gruijl is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Skin cancer & DNA repair. The author has an hindex of 46, co-authored 135 publications receiving 6223 citations. Previous affiliations of Frank R. de Gruijl include Leiden University & Utrecht University.
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UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer
TL;DR: Only the point mutations in the P53 gene from squamous cell carcinomas and BCCs, and in PTCH gene from BCC of xeroderma pigmentosum (XP) patients appear to be unambiguously attributable to solar UV radiation.
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Defective Transcription-Coupled Repair in Cockayne Syndrome B Mice Is Associated with Skin Cancer Predisposition
Gijsbertus T. J. van der Horst,Harry van Steeg,R. J. W. Berg,Alain J. van Gool,Jan de Wit,Geert Weeda,Hans Morreau,Rudolf B. Beems,Coen F. van Kreijl,Frank R. de Gruijl,Dirk Bootsma,Jan H.J. Hoeijmakers +11 more
TL;DR: It is demonstrated that transcription-coupled repair of UV-induced cyclobutane pyrimidine dimers contributes to the prevention of carcinogenesis in mice and suggested that the lack of cancer predisposition in CS patients is attributable to a global genome repair process that in humans is more effective than in rodents.
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The Influence of Painful Sunburns and Lifetime Sun Exposure on the Risk of Actinic Keratoses, Seborrheic Warts, Melanocytic Nevi, Atypical Nevi, and Skin Cancer
TL;DR: Lifetime sun exposure appeared to be associated with a lower risk of malignant melanoma, despite the fact that lifetime sun exposure did not diminish the number of melanocytic nevi or atypical nevi, and painful sunburns nor lifetimeSun exposure were associated with an increased risk of seborrheic warts.
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Photocarcinogenesis: UVA vs. UVB Radiation
TL;DR: Experiments have shown that UVA1 (340–400 nm) exposure induces SCC largely without the characteristic point mutations in p53, and much of the mutagenic and carcinogenic action of UVA radiation appears to be mediated through reactive oxygen species (ROS).
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Estimates of ozone depletion and skin cancer incidence to examine the Vienna Convention achievements.
TL;DR: A new method of estimating future excess skin cancer risks is presented which is used to compare effects of a 'no restrictions' scenario with two restrictive scenarios specified under the Vienna Convention: the Montreal Protocol, and the much stricter Copenhagen Amendments.