F
Frank Wappler
Researcher at Witten/Herdecke University
Publications - 232
Citations - 5100
Frank Wappler is an academic researcher from Witten/Herdecke University. The author has contributed to research in topics: Malignant hyperthermia & Skeletal muscle. The author has an hindex of 32, co-authored 228 publications receiving 4510 citations. Previous affiliations of Frank Wappler include University of Hamburg.
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Journal ArticleDOI
Dantrolene – A review of its pharmacology, therapeutic use and new developments
TL;DR: Dantrolene is not only used for the treatment of malignant hyperthermia, but also in the management of neuroleptic malignant syndrome, spasticity and Ecstasy intoxication, and its main disadvantage is its poor water solubility, and hence difficulties are experienced in rapidly preparing intravenous solutions in emergency situations.
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Trauma Associated Severe Hemorrhage (TASH)-Score: probability of mass transfusion as surrogate for life threatening hemorrhage after multiple trauma.
Nedim Yücel,Rolf Lefering,Marc Maegele,Matthias Vorweg,Thorsten Tjardes,Steffen Ruchholtz,Edmund Neugebauer,Frank Wappler,Bertil Bouillon,Dieter Rixen +9 more
TL;DR: In this paper, a simple scoring system that allows an early and reliable estimation for the probability of mass transfusion (MT) as a surrogate for life threatening hemorrhage following multiple trauma was developed.
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Evidence and consensus based guideline for the management of delirium, analgesia, and sedation in intensive care medicine. Revision 2015 (DAS-Guideline 2015) – short version
DAS-Taskforce,Ralf Baron,Andreas Binder,R. Biniek,Stephan Braune,Hartmut Buerkle,Peter Dall,Sueha Demirakca,Rahel Eckardt,Verena Eggers,Ingolf Eichler,Ingo Fietze,Stephan Freys,Andreas Fründ,Lars Garten,Bernhard Gohrbandt,Irene Harth,Wolfgang H. Hartl,Hans Jürgen Heppner,Johannes Horter,R. Huth,Uwe Janssens,Christine Jungk,Kristin Maria Kaeuper,Paul Kessler,Stefan Kleinschmidt,Matthias Kochanek,Matthias Kumpf,A. Meiser,Anika Mueller,Maritta Orth,Christian Putensen,Bernd Roth,Michael Schaefer,Rainhild Schaefers,Peter Schellongowski,Monika Schindler,Reinhard Schmitt,Jens Scholz,Stefan Schroeder,Gerhard Schwarzmann,Claudia Spies,Robert Stingele,Peter H. Tonner,Uwe Trieschmann,Michael Tryba,Frank Wappler,Christian Waydhas,Bjoern Weiss,Guido Weisshaar +49 more
TL;DR: This publication is a comprehensive, interdisciplinary, evidence and consensus-based set of level 3 guidelines for intensive care medicine, designed for all ICU professionals, and takes into account all critically ill patient populations.
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In vitro contracture test for diagnosis of malignant hyperthermia following the protocol of the European MH Group: Results of testing patients surviving fulminant MH and unrelated low-risk subjects
H. Ørding,V. Brancadoro,S. Cozzolino,F. R. Ellis,V. Glauber,E. F. Gonano,P. J. Halsall,E. Hartung,James J. A. Heffron,L. Heytens,G. Kozak‐Ribbens,H. Kress,R. Krtvosic‐Horber,Frank Lehmann-Horn,W. Mortier,Y Nivoche,E. Ranklev‐Twetman,S. Sigurdsson,M. Snoeck,Paul Stieglitz,Vincenzo Tegazzin,Albert Urwyler,Frank Wappler +22 more
TL;DR: Together EMHG sensitivity and specificity of the in vitro contracture test for malignant hyperthermia susceptibility using the European MH Group (EMHG) protocol is determined.
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Pre-operative evaluation of adults undergoing elective noncardiac surgery: Updated guideline from the European Society of Anaesthesiology.
Stefan De Hert,Sven Staender,Gerhard Fritsch,Jochen Hinkelbein,Arash Afshari,Gabriella Bettelli,Matthias Bock,Michelle S Chew,Mark Coburn,Edoardo De Robertis,Hendrik Drinhaus,Aarne Feldheiser,Götz Geldner,Daniel Lahner,Andrius Macas,Christopher Neuhaus,Simon Rauch,Maria Angeles Santos-Ampuero,Maurizio Solca,Nima Tanha,Vilma Traskaite,Gernot Wagner,Frank Wappler +22 more
TL;DR: The European Society of Anaesthesiology (ESA) guidelines on pre-operative evaluation of the adult undergoing noncardiac surgery are updated in this article, with recommendations based on the available relevant clinical evidence.