F
Franz Hofmann
Researcher at Technische Universität München
Publications - 477
Citations - 51857
Franz Hofmann is an academic researcher from Technische Universität München. The author has contributed to research in topics: Protein kinase A & Voltage-dependent calcium channel. The author has an hindex of 113, co-authored 471 publications receiving 49938 citations. Previous affiliations of Franz Hofmann include Ludwig Maximilian University of Munich & Heidelberg University.
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Journal ArticleDOI
Thrombocytosis as a response to high interleukin-6 levels in cGMP-dependent protein kinase I mutant mice.
Lin Zhang,Robert Lukowski,Florian Gaertner,Michael Lorenz,Kyle R. Legate,Katrin Domes,Elisabeth Angermeier,Franz Hofmann,Steffen Massberg +8 more
TL;DR: Dysfunction of cGMP/cGKI signaling in nonhematopoietic cells contributes to a high platelet count, which is potentially associated with thrombosis, and antibody-mediated blockade of interleukin-6 normalized platelet counts in cGKI-SM mice.
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Cyclic GMP-dependent protein kinase and smooth muscle relaxation.
TL;DR: It is unlikely that an unmodified I beta enzyme that occurs in high concentrations in vascular smooth muscle can be activated in vivo by cAMP, because approximately 10-fold higher concentrations of cyclic nucleotides were needed than the I alpha enzyme.
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Spatial memory deficits and motor coordination facilitation in cGMP-dependent protein kinase type II-deficient mice
Charlotte M. Wincott,Seonil Kim,Roseann F. Titcombe,David S. Tukey,Hiwot K. Girma,Joseph Pick,Loren M. DeVito,Franz Hofmann,Charles A. Hoeffer,Edward B. Ziff +9 more
TL;DR: It is shown that cGKII KO mice are significantly deficient in spatial learning while exhibiting facilitated motor coordination, demonstrating a clear dependence of memory-based tasks on cGkII.
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Cardiac sarcoplasmic reticulum contains a low‐affinity site for phenylakylamines
Hans-Jochem Oeken,Egbert von Nettelbladt,Manfred Zimmer,Veit Flockerzi,Peter Ruth,Franz Hofmann +5 more
TL;DR: It is suggested that free sarcoplasmic reticulum contains a binding site for phenylalkylamines at a relative high density, which is not related to the high-affinity site present in the voltage-dependent calcium channel.
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Solubilization of the bovine cardiac sarcolemmal binding sites for calcium channel blockers.
TL;DR: Nonionic and ionic detergents were used to solubilize the bovine cardiac sarcolemmal binding sites for nimodipine and (-)desmethoxyverapamil in the absence of added ligand and showed a similar rank order as the particulate binding sites.