F
Franz Müller-Spahn
Researcher at University of Basel
Publications - 126
Citations - 5651
Franz Müller-Spahn is an academic researcher from University of Basel. The author has contributed to research in topics: Receptor & Melatonin. The author has an hindex of 42, co-authored 126 publications receiving 5370 citations. Previous affiliations of Franz Müller-Spahn include Ludwig Maximilian University of Munich & Polish Academy of Sciences.
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Journal ArticleDOI
Decrease in parietal cerebral hemoglobin oxygenation during performance of a verbal fluency task in patients with Alzheimer's disease monitored by means of near-infrared spectroscopy (NIRS)--correlation with simultaneous rCBF-PET measurements.
Christoph Hock,Kersten Villringer,Franz Müller-Spahn,Rüdiger Wenzel,Hauke R. Heekeren,Sigrid Schuh-Hofer,Marc Hofmann,Satoshi Minoshima,Markus Schwaiger,Ulrich Dirnagl,Arno Villringer +10 more
TL;DR: In Alzheimer's disease a marked reduction of regional cerebral blood flow and cerebral hemoglobin oxygenation may occur during activation of brain function, probably mainly in degenerating brain areas, such as the parietal cortex.
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Amyloid β-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis
Uta Keil,Astrid Bonert,Celio A. Marques,Isabel Scherping,Jörg Weyermann,Joanna B. Strosznajder,Franz Müller-Spahn,Christian Haass,Christian Czech,Laurent Pradier,Walter E. Müller,Anne Eckert +11 more
TL;DR: A hypothetical sequence of pathogenic steps linking mutant APP expression and amyloid production with enhanced NO production and mitochondrial dysfunction finally leading to cell death is suggested, indicating a direct involvement of Aβ in these processes.
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Reduced hippocampal MT2 melatonin receptor expression in Alzheimer's disease.
Egemen Savaskan,Mohammed Akli Ayoub,Rivka Ravid,Debora Angeloni,Franco Fraschini,Fides Meier,Anne Eckert,Franz Müller-Spahn,Ralf Jockers +8 more
TL;DR: The results indicate that MT2 may be involved in mediating the effects of melatonin in the human hippocampus, and this mechanism may be heavily impaired in AD.
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Cortical alterations of angiotensin converting enzyme, angiotensin II and AT1 receptor in Alzheimer's dementia.
Egemen Savaskan,Christoph Hock,Gianfranco Olivieri,Sybille Bruttel,Carolyn Rosenberg,Christine M. Hulette,Franz Müller-Spahn +6 more
TL;DR: A prominent perivascular ACE and angiotensin II immunoreactivity surrounding some cortical vessels in aged controls and AD patients points to an underlying microvascular pathology in the process of neurodegeneration.
Journal ArticleDOI
Amyloid-beta leads to impaired cellular respiration, energy production and mitochondrial electron chain complex activities in human neuroblastoma cells.
Virginie Rhein,Ginette Baysang,S. Rao,Fides Meier,Astrid Bonert,Franz Müller-Spahn,Anne Eckert +6 more
TL;DR: Chronic exposure to soluble Aβ protein may result in an impairment of energy homeostasis due to a decreased respiratory capacity of mitochondrial electron transport chain which, in turn, may accelerate neurons demise.