F
Frédéric Lagarce
Researcher at University of Angers
Publications - 70
Citations - 2752
Frédéric Lagarce is an academic researcher from University of Angers. The author has contributed to research in topics: Nanocapsules & Temozolomide. The author has an hindex of 27, co-authored 68 publications receiving 2381 citations. Previous affiliations of Frédéric Lagarce include Université Nantes Angers Le Mans & French Institute of Health and Medical Research.
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Biopharmaceutical parameters to consider in order to alter the fate of nanocarriers after oral delivery
TL;DR: The gastrointestinal barrier and physiological stress factors with regard to nanocarriers' performance or integrity issues are described and the different characteristics offered by the nanoccarriers and their effect on the optimal transport of drug into the bloodstream are discussed.
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Enhanced oral paclitaxel bioavailability after administration of paclitaxel-loaded lipid nanocapsules.
TL;DR: The results indicated that LNC provided a promising new formulation to enhance the oral bioavailability of paclitaxel while avoiding the use of pharmacologically active P-gp inhibitors, such as verapamil.
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Lipid nanocarriers improve paclitaxel transport throughout human intestinal epithelial cells by using vesicle-mediated transcytosis.
TL;DR: Paclitaxel-loaded LNCs improved permeability of Ptx across intestinal epithelium compared with free Ptx or Taxol by a factor of 3.5 and transmission electronic microscopy showed the presence of nano-objects on the basolateral side of the Caco-2 cell monolayers when LNC's were applied on the apical side.
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Toward an effective strategy in glioblastoma treatment. Part I: resistance mechanisms and strategies to overcome resistance of glioblastoma to temozolomide
TL;DR: This review will describe the main mechanisms of GBM resistance to TMZ and different strategies developed to reverse the phenotype of these tumor cells and the drawbacks and limitations of these strategies.
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Development and characterization of a novel lipid nanocapsule formulation of Sn38 for oral administration
TL;DR: Sn38 nanocarriers have been developed and display a strong potential for oral administration and in vitro stability in gastrointestinal fluid and permeability across Caco-2 cells were tested.