F
Frederick C. de Beer
Researcher at University of Kentucky
Publications - 44
Citations - 2996
Frederick C. de Beer is an academic researcher from University of Kentucky. The author has contributed to research in topics: Serum amyloid A & Apolipoprotein B. The author has an hindex of 27, co-authored 44 publications receiving 2691 citations. Previous affiliations of Frederick C. de Beer include Veterans Health Administration.
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Journal ArticleDOI
Role of Group II Secretory Phospholipase A2 in Atherosclerosis : 1. Increased Atherogenesis and Altered Lipoproteins in Transgenic Mice Expressing Group IIa Phospholipase A2
Boris Ivandic,Lawrence W. Castellani,Xuping Wang,Jian-Hua Qiao,Margarete Mehrabian,Mohamad Navab,Alan M. Fogelman,David S. Grass,Mark E. Swanson,Maria C. de Beer,Frederick C. de Beer,Aldons J. Lusis +11 more
TL;DR: Data indicate that group IIa sPLA2 may promote atherogenesis, in part, through its effects on lipoprotein levels, and provide a possible mechanism for the observation that there is an increased incidence of coronary artery disease in many chronic inflammatory diseases.
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SR-BII, an isoform of the scavenger receptor BI containing an alternate cytoplasmic tail, mediates lipid transfer between high density lipoprotein and cells.
Nancy R. Webb,Patrice M. Connell,Gregory A. Graf,Eric J. Smart,Willem J.S. de Villiers,Frederick C. de Beer,Deneys R. van der Westhuyzen +6 more
TL;DR: These studies show that SR-BII, an HDL receptor isoform containing a distinctly different cytoplasmic tail, mediates selective lipid transfer between HDL and cells, but with a lower efficiency than the previously characterized variant.
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Hepatocytes direct the formation of a pro-metastatic niche in the liver
Jae W. Lee,Meredith L. Stone,Paige M. Porrett,Stacy K. Thomas,Chad A. Komar,Joey H. Li,Devora Delman,Kathleen Graham,Whitney L. Gladney,Xia Hua,Taylor A. Black,Austin L. Chien,Krishna S. Majmundar,Jeffrey C. Thompson,Stephanie S. Yee,Mark H. O'Hara,Charu Aggarwal,Dong Xin,Abraham Shaked,Mingming Gao,Dexi Liu,Mitesh J. Borad,Ramesh K. Ramanathan,Ramesh K. Ramanathan,Erica L. Carpenter,Ailing Ji,Maria C. de Beer,Frederick C. de Beer,Nancy R. Webb,Gregory L. Beatty +29 more
TL;DR: It is shown that hepatocytes coordinate myeloid cell accumulation and fibrosis within the liver and, in doing so, increase the susceptibility of the liver to metastatic seeding and outgrowth.
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Overexpression of Secretory Phospholipase A2 Causes Rapid Catabolism and Altered Tissue Uptake of High Density Lipoprotein Cholesteryl Ester and Apolipoprotein A-I
Uwe J. F. Tietge,Cyrille Maugeais,William Cain,David S. Grass,Jane M. Glick,Frederick C. de Beer,Daniel J. Rader +6 more
TL;DR: It is demonstrated that overexpression of sPLA2 alone in the absence of inflammation causes profound alterations of HDL metabolism in vivo and is consistent with the hypothesis that s PLA2 may promote HDL catabolism in acute and chronic inflammatory conditions.
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SR-BI protects against endotoxemia in mice through its roles in glucocorticoid production and hepatic clearance
TL;DR: It is concluded that scavenger receptor B-I in mice is required for the antiinflammatory response to LPS-induced endotoxic shock, likely through its essential role in facilitating glucocorticoid production and LPS hepatic clearance.