S
Stacy K. Thomas
Researcher at University of Pennsylvania
Publications - 11
Citations - 738
Stacy K. Thomas is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Immune system & Metastasis. The author has an hindex of 8, co-authored 8 publications receiving 524 citations. Previous affiliations of Stacy K. Thomas include National Institutes of Health & University of Connecticut Health Center.
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Journal ArticleDOI
Hepatocytes direct the formation of a pro-metastatic niche in the liver
Jae W. Lee,Meredith L. Stone,Paige M. Porrett,Stacy K. Thomas,Chad A. Komar,Joey H. Li,Devora Delman,Kathleen Graham,Whitney L. Gladney,Xia Hua,Taylor A. Black,Austin L. Chien,Krishna S. Majmundar,Jeffrey C. Thompson,Stephanie S. Yee,Mark H. O'Hara,Charu Aggarwal,Dong Xin,Abraham Shaked,Mingming Gao,Dexi Liu,Mitesh J. Borad,Ramesh K. Ramanathan,Ramesh K. Ramanathan,Erica L. Carpenter,Ailing Ji,Maria C. de Beer,Frederick C. de Beer,Nancy R. Webb,Gregory L. Beatty +29 more
TL;DR: It is shown that hepatocytes coordinate myeloid cell accumulation and fibrosis within the liver and, in doing so, increase the susceptibility of the liver to metastatic seeding and outgrowth.
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Memory T cell–driven differentiation of naive cells impairs adoptive immunotherapy
Christopher A. Klebanoff,Christopher D. Scott,Anthony J. Leonardi,Tori N. Yamamoto,Tori N. Yamamoto,Anthony C. Cruz,Claudia Ouyang,Madhu Ramaswamy,Madhu Ramaswamy,Rahul Roychoudhuri,Yun Ji,Robert L. Eil,Madhusudhanan Sukumar,Joseph G. Crompton,Douglas C. Palmer,Zachary A. Borman,David Clever,David Clever,Stacy K. Thomas,Patel Shashankkumar J,Patel Shashankkumar J,Zhiya Yu,Pawel Muranski,Hui Liu,Ena Wang,Francesco M. Marincola,Alena Gros,Luca Gattinoni,Steven A. Rosenberg,Richard M. Siegel,Nicholas P. Restifo +30 more
TL;DR: It is revealed that T cell subsets can synchronize their differentiation state in a process similar to quorum sensing in unicellular organisms and suggested that disruption of this quorum-like behavior among T cells has potential to enhance T cell-based immunotherapies.
Journal ArticleDOI
Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor
Qingshan Fu,Tian-Min Fu,Tian-Min Fu,Anthony C. Cruz,Prabuddha Sengupta,Stacy K. Thomas,Shuqing Wang,Richard M. Siegel,Hao Wu,Hao Wu,James J. Chou +10 more
TL;DR: The NMR structures of mouse and human Fas TM domains in bicelles that mimic lipid bilayers are determined and suggest that the structures represent the signaling-active conformation of Fas TM, which appears to be different from the pre-ligand conformation.
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Global Regulation of the Histone Mark H3K36me2 Underlies Epithelial Plasticity and Metastatic Progression.
Salina Yuan,Ramakrishnan Natesan,Francisco J. Sánchez-Rivera,Jinyang Li,Natarajan V. Bhanu,Taiji Yamazoe,Jeffrey H. Lin,Allyson J. Merrell,Yogev Sela,Stacy K. Thomas,Yanqing Jiang,Jacqueline B Plesset,Emma M. Miller,Junwei Shi,Benjamin A. Garcia,Scott W. Lowe,Scott W. Lowe,Irfan A. Asangani,Ben Z. Stanger +18 more
TL;DR: Using a K-to-M histone mutant to directly inhibit H3K36me2, it is found that global modulation of the mark is a conserved mechanism underlying the mesenchymal state in various contexts.
Journal ArticleDOI
Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction.
Anthony C. Cruz,Madhu Ramaswamy,Claudia Ouyang,Christopher A. Klebanoff,Prabuddha Sengupta,Tori N. Yamamoto,Françoise Meylan,Stacy K. Thomas,Nathan Richoz,Robert L. Eil,Susan Price,Rafael Casellas,V. Koneti Rao,Jennifer Lippincott-Schwartz,Nicholas P. Restifo,Richard M. Siegel +15 more
TL;DR: It is shown that a palmitoylation-defective Fas C194V mutant is defective in inducing apoptosis in primary mouse T cells, B cells and dendritic cells, while retaining the ability to enhance naive T-cell differentiation.