D
Dong Xin
Researcher at University of Pennsylvania
Publications - 4
Citations - 282
Dong Xin is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 4, co-authored 4 publications receiving 184 citations. Previous affiliations of Dong Xin include Children's Hospital of Philadelphia.
Papers
More filters
Journal ArticleDOI
Hepatocytes direct the formation of a pro-metastatic niche in the liver
Jae W. Lee,Meredith L. Stone,Paige M. Porrett,Stacy K. Thomas,Chad A. Komar,Joey H. Li,Devora Delman,Kathleen Graham,Whitney L. Gladney,Xia Hua,Taylor A. Black,Austin L. Chien,Krishna S. Majmundar,Jeffrey C. Thompson,Stephanie S. Yee,Mark H. O'Hara,Charu Aggarwal,Dong Xin,Abraham Shaked,Mingming Gao,Dexi Liu,Mitesh J. Borad,Ramesh K. Ramanathan,Ramesh K. Ramanathan,Erica L. Carpenter,Ailing Ji,Maria C. de Beer,Frederick C. de Beer,Nancy R. Webb,Gregory L. Beatty +29 more
TL;DR: It is shown that hepatocytes coordinate myeloid cell accumulation and fibrosis within the liver and, in doing so, increase the susceptibility of the liver to metastatic seeding and outgrowth.
Journal ArticleDOI
Genetic and Epigenetic Fine Mapping of Complex Trait Associated Loci in the Human Liver
Minal Çalışkan,Elisabetta Manduchi,Elisabetta Manduchi,H. Shanker Rao,Julian A. Segert,Marcia Holsbach Beltrame,Marco Trizzino,YoSon Park,Samuel W. Baker,Alessandra Chesi,Matthew E. Johnson,Kenyaita M. Hodge,Michelle E. Leonard,Bao-Li Loza,Dong Xin,Andrea M Berrido,Nicholas J. Hand,Robert C. Bauer,Andrew D. Wells,Andrew D. Wells,Kim M. Olthoff,Abraham Shaked,Daniel J. Rader,Struan F.A. Grant,Christopher D. Brown +24 more
TL;DR: A repertoire of genes and regulatory mechanisms governing complex disease development and epigenetic regulation of gene expression in the human liver tissue is revealed and widespread functional consequences of natural genetic variation on putative regulatory element activity and gene expression levels are demonstrated.
Journal ArticleDOI
Severe Preservation Injury Induces Il‐6/STAT3 Activation with Lack of Cell Cycle Progression After Partial Liver Graft Transplantation
Fotini Debonera,Fotini Debonera,Guodong Wang,Guodong Wang,Jinfu Xie,Jinfu Xie,Xingye Que,Andrew E. Gelman,Andrew E. Gelman,Cynthia LeClair,Dong Xin,Dong Xin,Abraham Shaked,Abraham Shaked,Kim M. Olthoff,Kim M. Olthoff +15 more
TL;DR: The outcome of partial liver grafts in comparison to whole grafts following CIR injury is examined in patients undergoing partial liver transplantation to overcome severe donor shortage.
Posted ContentDOI
Genetic And Epigenetic Fine Mapping Of Complex Trait Associated Loci In The Human Liver
Minal Çalışkan,Elisabetta Manduchi,H. Shanker Rao,Julian A. Segert,Marcia Holsbach Beltrame,Marco Trizzino,YoSon Park,Samuel W. Baker,Alessandra Chesi,Matthew E. Johnson,Kenyaita M. Hodge,Michelle E. Leonard,Bao-Li Loza,Dong Xin,Andrea M Berrido,Nicholas J. Hand,Robert C. Bauer,Andrew D. Wells,Kim M. Olthoff,Abraham Shaked,Daniel J. Rader,Struan F.A. Grant,Christopher D. Brown +22 more
TL;DR: The most comprehensive genome-wide dataset of two epigenetic marks, H3K4me3 andH3K27ac, is generated and thousands of putative regulatory elements in the human liver are annotated, contributing to the repertoire of genes and regulatory mechanisms governing complex disease development and further the basic understanding of genetic and epigenetic regulation of gene expression in thehuman liver tissue.