F
Frederick E. Sieber
Researcher at Johns Hopkins Bayview Medical Center
Publications - 104
Citations - 5089
Frederick E. Sieber is an academic researcher from Johns Hopkins Bayview Medical Center. The author has contributed to research in topics: Delirium & Hip fracture. The author has an hindex of 33, co-authored 94 publications receiving 4386 citations. Previous affiliations of Frederick E. Sieber include Johns Hopkins University School of Medicine & Johns Hopkins University.
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Journal ArticleDOI
Neurodegeneration in Excitotoxicity, Global Cerebral Ischemia, and Target Deprivation: A Perspective on the Contributions of Apoptosis and Necrosis
Lee J. Martin,Nael A. Al-Abdulla,Ansgar M. Brambrink,Jeffrey R. Kirsch,Frederick E. Sieber,Carlos Portera-Cailliau +5 more
TL;DR: It is found that N-methyl-D-aspartate (NMDA) receptor- and non-NMDA receptor-mediated excitotoxic injury results in neurodegeneration along an apoptosis-necrosis continuum, in which neuronal death is influenced by the degree of brain maturity and the subtype of glutamate receptor that is stimulated.
Journal ArticleDOI
Sedation Depth During Spinal Anesthesia and the Development of Postoperative Delirium in Elderly Patients Undergoing Hip Fracture Repair
Frederick E. Sieber,Khwaji J. Zakriya,Allan Gottschalk,Mary Rita Blute,Hochang B. Lee,Paul B. Rosenberg,Simon C. Mears +6 more
TL;DR: Limiting depth of sedation during spinal anesthesia is a simple, safe, and cost-effective intervention for preventing postoperative delirium in elderly patients that could be widely and readily adopted.
Sedation Depth During Spinal Anesthesia and the Development of Postoperative Delirium in Elderly Patients Undergoing Hip Fracture Repair ORIGINAL ARTICLE
Frederick E. Sieber,Khwaji J. Zakriya,Allan Gottschalk,Mary-Rita Blute,Hochang B. Lee,Paul B. Rosenberg,Simon C. Mears +6 more
TL;DR: In this paper, a double-blind, randomized controlled trial at an academic medical center of elderly patients (≥65 years) without preoperative delirium or severe dementia who underwent hip fracture repair under spinal anesthesia with propo- fol sedation was performed.
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Intraoperative Infusion of Dexmedetomidine for Prevention of Postoperative Delirium and Cognitive Dysfunction in Elderly Patients Undergoing Major Elective Noncardiac Surgery: A Randomized Clinical Trial.
Stacie Deiner,Xiaodong Luo,Hung-Mo Lin,Daniel I. Sessler,Leif Saager,Frederick E. Sieber,Hochang B. Lee,Mary Sano,Christopher J. Jankowski,Sergio D. Bergese,Keith A. Candiotti,Joseph H. Flaherty,Harendra Arora,Aryeh Shander,Peter Rock +14 more
TL;DR: The reduction inDelirium previously demonstrated in numerous surgical intensive care unit studies was not observed, which underscores the importance of timing when administering the drug to prevent delirium.
Journal ArticleDOI
Special issues: Glucose and the brain
TL;DR: Moderate hypoglycemia may evoke a significant stress response, behavioral changes, and alterations in cerebral blood flow and metabolism, which must be addressed when caring for patients with cerebral ischemia or intracranial compliance problems.