J
Jeffrey R. Kirsch
Researcher at Oregon Health & Science University
Publications - 157
Citations - 5669
Jeffrey R. Kirsch is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Cerebral blood flow & Ischemia. The author has an hindex of 41, co-authored 156 publications receiving 5429 citations. Previous affiliations of Jeffrey R. Kirsch include Johns Hopkins University School of Medicine & National Institutes of Health.
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Journal ArticleDOI
Neurodegeneration in Excitotoxicity, Global Cerebral Ischemia, and Target Deprivation: A Perspective on the Contributions of Apoptosis and Necrosis
Lee J. Martin,Nael A. Al-Abdulla,Ansgar M. Brambrink,Jeffrey R. Kirsch,Frederick E. Sieber,Carlos Portera-Cailliau +5 more
TL;DR: It is found that N-methyl-D-aspartate (NMDA) receptor- and non-NMDA receptor-mediated excitotoxic injury results in neurodegeneration along an apoptosis-necrosis continuum, in which neuronal death is influenced by the degree of brain maturity and the subtype of glutamate receptor that is stimulated.
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Oxygen radical mechanisms of brain injury following ischemia and reperfusion
TL;DR: Current understanding of oxygen radical mechanisms as they relate to the brain during ischemia and reperfusion is addressed and lipid-soluble antioxidants appear more efficacious because of their ability to cross the blood-brain barrier and their presence in membrane structures where peroxidative reactions can be halted.
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Inhalational anesthetics as neuroprotectants or chemical preconditioning agents in ischemic brain
TL;DR: This review will focus on inhalationalAnesthetic neuroprotection during cerebral ischemia and inhalational anesthetic preconditioning before ischemic brain injury and mechanisms underlying volatile anesthetic neuro protection and preconditionsing will be examined.
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Effects of anesthesia on cerebral blood flow, metabolism, and neuroprotection:
TL;DR: The physiological determinants of cerebral blood flow are reviewed and how delivery of anesthesia impacts these processes are reviewed.
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Postischemic cerebral blood flow recovery in the female: Effect of 17β-estradiol
Patricia D. Hurn,Marguerite T. Littleton-Kearney,Jeffrey R. Kirsch,Arunasalam Dharmarajan,Richard J. Traystman +4 more
TL;DR: It is concluded that chronic exogenous 17β-estradiol treatment increases CBF during global incomplete ischemia and ameliorates postischemic hyperemia in the female animal.