Fredric R. Boockfor

TL;DR: A synthetic fragment was added to the firefly luciferase-coding sequence that encoded the proteolytic "PEST" signal from mouse ornithine decarboxylase that displayed a functional half-life of 0.84 h compared to 3.68 h for the wild-type enzyme.

TL;DR: Maximal plaque development by somatotropes could be induced within 30 min of administering large doses of GRF, indicating that most, if not all somatotropic cells are responsive to this secretagogue, and suggests that mammotropes are heterogeneous with respect to TRH responsiveness.

TL;DR: The results suggest that PRL, but not GH, cells from these pituitary regions are differentially responsive to at least two hypothalamic secretagogues, and raise the possibility that the release of PRL from mammotropes and mammosomatotropes is regulated differently and that the ratio of these two cell types may dictate, in part, the manner in which a specific region of the pituitsary responds to hypothalamic input.

TL;DR: The results demonstrate very clearly that certain cytokines acting in a stage specific manner have acute and/or chronic influences on the release of TF from Sertoli cells, and suggest strongly that cytokines or cytokine-like substances, by modulating therelease of SERToli cell substances, may play an important role in testis function.

TL;DR: The results provide strong evidence that the GnRH pulse generator in GT1-7 cells arises from a single cell oscillator mechanism that is synchronized through network signaling involving voltage-gated calcium channels and gap junctions.