W J Faught

TL;DR: A synthetic fragment was added to the firefly luciferase-coding sequence that encoded the proteolytic "PEST" signal from mouse ornithine decarboxylase that displayed a functional half-life of 0.84 h compared to 3.68 h for the wild-type enzyme.

TL;DR: Results substantiate the hypothesis that acidophilic subpopulations are capable of transdifferentiation given an appropriate hormonal signal and discount the possibility that effects were due to selective cell proliferation.

TL;DR: The results demonstrate the validity of the "real-time" strategy for dynamically monitoring GnRH gene activity in living neurons and indicate that Gn RH gene expression as well as neuropeptide release can occur in an intermittent manner.

TL;DR: The authors' results showed that the majority of mammotropes exhibited distinct oscillatory behaviors that could be subgrouped on the basis of frequency/amplitude of [Ca2+]i changes, whereas the remainder were quiescent (nonoscillatory), suggesting that dynamic changes in PRL gene expression may be regulated by temporally dissociated transitions betweenQuiescent and oscillatory states.

TL;DR: Results strongly suggest that during the estrous cycle there is a bidirectional interconversion among cells that release only GH and mammosomatotropes and the relationship between ratios of acidophilic subpopulations and stage of reproductive cycle indicates that ovarian steroids may regulate this phenomenon.