Fredrik Ivars

TL;DR: It is found that CD4+CD25+ T cells down‐regulated the expression of the co‐stimulatory molecules CD80 and CD86 on dendritic cells, suggesting that distinct mechanisms regulate theexpression of these molecules.

TL;DR: It is shown here that macrophage-derived gelatinase (matrix metalloproteinase [MMP]-2 and MMP-9) activity is crucial for leukocytes penetration of the parenchymal BM, the first description of selective in situ proteolytic damage of a BBB-specific molecule at sites of leukocyte infiltration.

TL;DR: It is proposed that Treg cells down‐modulate B7‐molecules on DCs in a CTLA‐4‐dependent way, thereby enhancing suppression of T‐cell activity.

TL;DR: The specific binding of quinoline-3-carboxamides to S100A9 explains the immunomodulatory activity of this class of compounds and defines S 100A9 as a novel target for treatment of human autoimmune diseases.

TL;DR: It is shown that targeting lymphocyte interactions with endothelial basement membrane laminins provides a means of inhibiting disease without compromising innate immune responses, and that T lymphocytes use mechanisms distinct from other immune cells to penetrate the endothelium basement membrane barrier.