E
Elisabeth Georges-Labouesse
Researcher at French Institute of Health and Medical Research
Publications - 25
Citations - 2370
Elisabeth Georges-Labouesse is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Integrin & Laminin. The author has an hindex of 18, co-authored 25 publications receiving 2211 citations. Previous affiliations of Elisabeth Georges-Labouesse include Centre national de la recherche scientifique.
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Journal ArticleDOI
Essential role of α6 integrins in cortical and retinal lamination
TL;DR: Evidence is provided for an essential role of integrin-laminin interactions in the proper development of the nervous system in mice lacking integrin alpha 6.
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CNS integrins switch growth factor signalling to promote target-dependent survival.
Holly Colognato,Wia Baron,Virginia Avellana-Adalid,João B. Relvas,Anne Baron-Van Evercooren,Elisabeth Georges-Labouesse,Charles ffrench-Constant +6 more
TL;DR: It is shown that myelin-forming oligodendrocytes activate an integrin-regulated switch in survival signalling when they contact axonal laminins, which reverses the capacity of neuregulin to inhibit the differentiation of precursors, thereby explaining how neurgulin subsequently promotes differentiation and survival in myelinating oligodends.
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Integrin and ECM functions: roles in vertebrate development
TL;DR: The analysis of mutant mice is bringing novel insights on the role of extracellular matrix (ECM) and integrin receptors during a variety of physiological processes, including embryonic development.
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Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse
TL;DR: The presence of novel phenotypes in double mutant embryos demonstrates the synergism between alpha3 and alpha6 integrins and their essential roles in multiple processes during embryogenesis.
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Endothelial basement membrane laminin alpha5 selectively inhibits T lymphocyte extravasation into the brain.
Chuan Wu,Fredrik Ivars,Per Anderson,Rupert Hallmann,Dietmar Vestweber,Per Nilsson,Horst Robenek,Karl Tryggvason,Jian Song,Eva Korpos,Karin Loser,Stefan Beissert,Elisabeth Georges-Labouesse,Lydia Sorokin +13 more
TL;DR: It is shown that targeting lymphocyte interactions with endothelial basement membrane laminins provides a means of inhibiting disease without compromising innate immune responses, and that T lymphocytes use mechanisms distinct from other immune cells to penetrate the endothelium basement membrane barrier.