Fredrik Vult von Steyern

TL;DR: The hypothesis that the NAB2/STAT6 fusions will result in altered properties of the transcriptional co‐repressor NAB 2 ‐ a key regulator of the early growth response 1 (EGR1) transcription factor – was corroborated by global gene expression analysis; SFTs showed deregulated expression of EGR1 target genes, as well as of other, developmentally important genes.

TL;DR: In this paper, the authors used chromosome banding analysis, fluorescence in situ hybridization (FISH), mRNA sequencing, RT-PCR and quantitative real-time PCR on a series of morphologically well-characterized pseudomyogenic haemangioendothelioma (PHE) to show that a balanced translocation, t(7;19)(q22;q13), detected as the sole cytogenetic aberration in two cases, results in fusion of the SERPINE1 and FOSB genes.

TL;DR: The results suggest that this tumor constitutes an interesting model for evaluating the cellular effects of AHR signaling, and global gene expression analysis showed upregulation of CYP1A1 as well as other typical target genes of this pathway, such as those encoding toll‐like receptors.

TL;DR: Despite R0 resection, two-thirds of the patients developed a local recurrence and the prognosis was dismal and median DSS was just over 3 years.

TL;DR: In this paper, the authors identified different structural rearrangements of chromosome band 6p21 in tumor cells from three cases of osteogenesis fibromyxoid tumor (OFMT), including one with typical, one with atypical, and one with malignant morphological features.