F
Frieder Keller
Researcher at University of Ulm
Publications - 163
Citations - 4349
Frieder Keller is an academic researcher from University of Ulm. The author has contributed to research in topics: Renal function & Pharmacokinetics. The author has an hindex of 33, co-authored 159 publications receiving 4045 citations.
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Journal ArticleDOI
Pharmacokinetics and Pharmacodynamics of Systemically Administered Glucocorticoids
TL;DR: Simulations with a pharmacokinetic/pharmacodynamic model using T helper cell counts and endogenous Cortisol as biomarkers for the effects of methylprednisolone suggest that the clinical efficacy of low-dose glucocorticoid regimens might be increased with twice-daily glucocORTicoid administration.
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Drug dosing consideration in patients with acute and chronic kidney disease-a clinical update from Kidney Disease: Improving Global Outcomes (KDIGO).
Gary R. Matzke,George R. Aronoff,Arthur J. Atkinson,William M. Bennett,Brian S. Decker,Kai-Uwe Eckardt,Thomas A. Golper,Darren W. Grabe,Bertram L. Kasiske,Frieder Keller,Jan T. Kielstein,Ravindra L. Mehta,Bruce A. Mueller,Deborah A. Pasko,Franz Schaefer,Domenic A. Sica,Lesley A. Inker,Jason G. Umans,Patrick T. Murray +18 more
TL;DR: The KDIGO Conference highlighted the gaps and focused on crafting paths to the future that will stimulate research and improve the global outcomes of patients with acute and chronic kidney disease.
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Review on Pharmacokinetics and Pharmacodynamics and the Aging Kidney
TL;DR: The analysis of NEPharm records revealed an average age-related prolongation of half-life of 1.39-fold (corresponding to +39 +/- 61%).
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Increased expression of TGF-β1 and IGF-I in inflammatory stenotic lesions of hemodialysis fistulas
Sylvia Stracke,Klaus Konner,Isabella Köstlin,Reinhard Friedl,Peter M. Jehle,Vinzenz Hombach,Frieder Keller,Johannes Waltenberger +7 more
TL;DR: Neointimal thickening of primary arteriovenous fistulas represents a local inflammatory process and appears to be associated with increased protein expression of TGF-beta1 and IGF-I.
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Mechanism-based pharmacokinetic-pharmacodynamic modeling of antimicrobial drug effects.
David Czock,Frieder Keller +1 more
TL;DR: It is shown that most of the published mathematical models can be derived from one common mechanism-based PK–PD model premised on cell growth and cell killing processes, and a new equation predicting the time to microorganisms eradication after repeated drug doses was derived.