F
Fumiaki Kojima
Researcher at Kitasato University
Publications - 47
Citations - 1940
Fumiaki Kojima is an academic researcher from Kitasato University. The author has contributed to research in topics: Prostaglandin & Inflammation. The author has an hindex of 17, co-authored 42 publications receiving 1811 citations. Previous affiliations of Fumiaki Kojima include University of Kentucky & Asahikawa Medical University.
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Journal ArticleDOI
Regulation of Prostaglandin E2 Biosynthesis by Inducible Membrane-associated Prostaglandin E2 Synthase That Acts in Concert with Cyclooxygenase-2
Makoto Murakami,Hiroaki Naraba,Toshihiro Tanioka,Natsuki Semmyo,Yoshihito Nakatani,Fumiaki Kojima,Tomomi Ikeda,Mai Fueki,Akinori Ueno,Sachiko Oh-ishi,Ichiro Kudo +10 more
TL;DR: COX-2 and mPGES are essential components for delayed PGE2 biosynthesis, which may be linked to inflammation, fever, osteogenesis, and even cancer.
Journal Article
Coexpression of microsomal prostaglandin E synthase with cyclooxygenase-2 in human rheumatoid synovial cells
TL;DR: The results suggest that abundant PGE2 production at inflammation sites such as rheumatoid synovia is caused by the coordinated upregulation of mPGES and COX-2.
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Roles of prostanoids in the pathogenesis of cardiovascular diseases: Novel insights from knockout mouse studies.
Koh-ichi Yuhki,Fumiaki Kojima,Hitoshi Kashiwagi,Jun-ichi Kawabe,Takayuki Fujino,Shuh Narumiya,Fumitaka Ushikubi +6 more
TL;DR: Roles of prostanoids in the development of cardiovascular diseases, such as acute myocardial infarction, cardiac hypertrophy, atherosclerosis, vascular remodeling, hypertension and cerebral thrombosis are summarized.
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The intrinsic prostaglandin E2–EP4 system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice
Naoki Nakagawa,Koh-ichi Yuhki,Jun-ichi Kawabe,Takayuki Fujino,Osamu Takahata,Maki Kabara,Kazutoshi Abe,Fumiaki Kojima,Hitoshi Kashiwagi,Naoyuki Hasebe,Kenjiro Kikuchi,Yukihiko Sugimoto,Shuh Narumiya,Fumitaka Ushikubi +13 more
TL;DR: An endogenous PGE(2)-EP(4) system in the tubular epithelium limits the development of tubulointerstitial fibrosis by suppressing inflammatory responses.
Journal ArticleDOI
Defective Generation of a Humoral Immune Response Is Associated with a Reduced Incidence and Severity of Collagen-Induced Arthritis in Microsomal Prostaglandin E Synthase-1 Null Mice
Fumiaki Kojima,Mohit Kapoor,Lihua Yang,Erica L. Fleishaker,Martin R. Ward,Seetha U. Monrad,Ponnappa C. Kottangada,Charles Q. Pace,James A. Clark,Jerold G. Woodward,Leslie J. Crofford +10 more
TL;DR: It is demonstrated for the first time that deficiency of mPGES-1 inhibits the development of collagen-induced arthritis, at least in part, by blocking theDevelopment of a humoral immune response against type II collagen.