Fumihide Ogawa

TL;DR: To identify the 140-kd autoantigen recognized by anti-155/140 autoantibodies that are associated with adult cancer-associated dermatomyositis and juvenile DM and to determine the clinical relevance of anti- 155/140 antibodies in a large cohort is determined.

TL;DR: It is suggested that bleomycin induces fibrosis by enhancing hyaluronan production, which activates B cells to produce fibrogenic cytokines mainly via TLR4 and induce autoantibody production, and that CD19 deficiency suppresses fibrosis and autoantibia production by inhibitingTLR4 signals.

TL;DR: It is suggested that L-selectin and ICAM-1 regulate Th2 and Th17 cell accumulation into the skin and lung, leading to the development of fibrosis, and that P- selectin, E-select in, and PSGL-1 regulates Th1 cell infiltration, resulting in the inhibition of fibritis.

TL;DR: This study is the first to show that rapamycin has a significant inhibitory effect on fibrosis in both TSK/+ and bleomycin-induced SSc model mice, and suggests thatRapamycin might be an attractive candidate for clinical trials in SSc patients.

TL;DR: It is suggested that IgE anti-BP180 Abs are related to the disease severity and activity of BP, and it may be possible to identify treatment-refractory patients with BP more specifically by assessing the presence or levels of IgE against BP in those with a high IgG anti- BP180 Ab titer.