N
Naohito Hatta
Researcher at Kanazawa University
Publications - 76
Citations - 2634
Naohito Hatta is an academic researcher from Kanazawa University. The author has contributed to research in topics: Melanoma & Metastasis. The author has an hindex of 28, co-authored 73 publications receiving 2339 citations. Previous affiliations of Naohito Hatta include Newcastle University.
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Journal ArticleDOI
Myositis-specific anti-155/140 autoantibodies target transcription intermediary factor 1 family proteins.
Manabu Fujimoto,Yasuhito Hamaguchi,Kenzo Kaji,Takashi Matsushita,Yuki Ichimura,Masanari Kodera,Naoko Ishiguro,Ikuko Ueda-Hayakawa,Yoshihide Asano,Fumihide Ogawa,Keita Fujikawa,Takuya Miyagi,Eriko Mabuchi,Kenji Hirose,Narihiro Akimoto,Naohito Hatta,Kiyohiro Tsutsui,Akira Higashi,Atsuyuki Igarashi,Mariko Seishima,Minoru Hasegawa,Kazuhiko Takehara +21 more
TL;DR: To identify the 140-kd autoantigen recognized by anti-155/140 autoantibodies that are associated with adult cancer-associated dermatomyositis and juvenile DM and to determine the clinical relevance of anti- 155/140 antibodies in a large cohort is determined.
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Extramammary Paget’s disease: treatment, prognostic factors and outcome in 76 patients
TL;DR: A large number of EMPD tumours are in situ and invasive EMPD has a poor prognosis, so it is necessary to select patients suitable for surgery on the basis of their prognosis.
Journal Article
Melanoma metastasis suppression by chromosome 6: evidence for a pathway regulated by CRSP3 and TXNIP.
Steven F. Goldberg,Mary E. Miele,Naohito Hatta,Minoru Takata,Carrie Paquette-Straub,Leonard P. Freedman,Leonard P. Freedman,Danny R. Welch,Danny R. Welch,Danny R. Welch +9 more
TL;DR: Quantitative real-time reverse-transcription PCR of clinical melanoma samples showed that loss of CRSP3 expression correlated with decreased KISS1 expression and increased metastasis, implicated a specific gene on chromosome 6 in the etiology of melanoma metastasis and identified potential up-stream regulators of KISS 1 and TXNIP.
Journal Article
Loss of Expression of the Metastasis Suppressor Gene KiSS1 during Melanoma Progression and Its Association with LOH of Chromosome 6q16.3-q23
TL;DR: The findings in this study show, for the first time, KiSS1 down- regulation during the progression of melanoma in vivo and strongly suggest that inactivation of a tumor suppressor gene(s) mapping to 6q16.3-q23 by deletion or mutation coupled with LOH may lead to the down-regulation of KiSS 1.
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High Frequency of BRAFV600E Mutation in Acquired Nevi and Small Congenital Nevi, but Low Frequency of Mutation in Medium-Sized Congenital Nevi
Nami Ichii-Nakato,Minoru Takata,Shuko Takayanagi,Shiho Takashima,J. Lin,Hiroshi Murata,Akihide Fujimoto,Naohito Hatta,Toshiaki Saida +8 more
TL;DR: The results strongly suggest that UV light is not necessarily required for the acquisition of the BRAF(V600E) mutation, and suggest that non-mutagenic effects of UV light to melanocytes may be more important in the nevogenesis.