Journal ArticleDOI
Myositis-specific anti-155/140 autoantibodies target transcription intermediary factor 1 family proteins.
Manabu Fujimoto,Yasuhito Hamaguchi,Kenzo Kaji,Takashi Matsushita,Yuki Ichimura,Masanari Kodera,Naoko Ishiguro,Ikuko Ueda-Hayakawa,Yoshihide Asano,Fumihide Ogawa,Keita Fujikawa,Takuya Miyagi,Eriko Mabuchi,Kenji Hirose,Narihiro Akimoto,Naohito Hatta,Kiyohiro Tsutsui,Akira Higashi,Atsuyuki Igarashi,Mariko Seishima,Minoru Hasegawa,Kazuhiko Takehara +21 more
Reads0
Chats0
TLDR
To identify the 140-kd autoantigen recognized by anti-155/140 autoantibodies that are associated with adult cancer-associated dermatomyositis and juvenile DM and to determine the clinical relevance of anti- 155/140 antibodies in a large cohort is determined.Abstract:
Objective
To identify the 140-kd autoantigen recognized by anti-155/140 autoantibodies that are associated with adult cancer-associated dermatomyositis (DM) and juvenile DM and to determine the clinical relevance of anti-155/140 antibodies in a large cohort.
Methods
Sera from 456 DM patients were assessed for the presence of anti-155/140 antibodies by immunoprecipitation using K562 cell extracts as substrate. Using immunoprecipitation and Western blotting, we then examined whether anti-155/140–positive sera recognized transcription intermediary factor 1α (TIF-1α), TIF-1β, and TIF-1γ. The clinical associations of antigen reactivity were also evaluated.
Results
Anti-155/140–positive sera reacted with 140-kd TIF-1α in addition to 155-kd TIF-1γ. Among sera from 456 DM patients, 52 were reactive with both TIF-1α and TIF-1γ, while another 25 were reactive with TIF-1γ alone. Additionally, 7 were reactive with TIF-1β. Malignancy was more frequently found in adult patients with both anti–TIF-1α and anti–TIF-1γ antibodies than in those with anti–TIF-1γ antibodies alone (73% versus 50%; P < 0.05). In addition to juvenile DM patients and middle-aged and older DM patients with high percentages of malignancy, 8 “young adult” DM patients without malignancy had these autoantibodies.
Conclusion
Anti-155/140 antibodies target TIF-1 family proteins, TIF-1α and TIF-1β, in addition to TIF-1γ. Since TIF-1 proteins have significant roles in oncogenesis, these antibodies may be produced during misdirected antitumor immunity.read more
Citations
More filters
Journal ArticleDOI
Most Patients With Cancer-Associated Dermatomyositis Have Antibodies to Nuclear Matrix Protein NXP-2 or Transcription Intermediary Factor 1γ
David Fiorentino,Lorinda Chung,Lisa Christopher-Stine,Lisa C. Zaba,Shufeng Li,Andrew L. Mammen,Antony Rosen,Livia Casciola-Rosen +7 more
TL;DR: These studies demonstrate that anti-NXP-2 and anti-TIF-1γ antibodies are frequent DM specificities and are present in most patients with cancer-associated DM.
Journal ArticleDOI
Common and distinct clinical features in adult patients with anti-aminoacyl-tRNA synthetase antibodies: heterogeneity within the syndrome.
Yasuhito Hamaguchi,Manabu Fujimoto,Takashi Matsushita,Kenzo Kaji,Kazuhiro Komura,Minoru Hasegawa,Masanari Kodera,Eiji Muroi,Keita Fujikawa,Mariko Seishima,Hidehiro Yamada,Ryo Yamada,Shinichi Sato,Kazuhiko Takehara,Masataka Kuwana +14 more
TL;DR: Identification of individual anti-ARS Abs is beneficial to define this rather homogeneous subset and to predict clinical outcomes within the “anti-synthetase syndrome.”
Journal ArticleDOI
Myositis-specific autoantibodies: an important tool to support diagnosis of myositis.
Z. Betteridge,N. A. McHugh +1 more
TL;DR: Preliminary studies investigating correlations between specific myositis autoantibody titres and clinical markers of disease course are discussed, collectively demonstrating the utility of myositic inflammatory myopathies as both diagnostic and prognostic marker of disease.
Journal ArticleDOI
A Comprehensive Overview on Myositis-Specific Antibodies: New and Old Biomarkers in Idiopathic Inflammatory Myopathy.
TL;DR: Classic MSAs known for over 30 years include antibodies to Jo-1 and other aminoacyl tRNA synthetases (ARS), anti-Mi-2, and anti-signal recognition particle (SRP), and several new autoantibodies with strong clinical significance have been described in DM.
Journal ArticleDOI
The myositis autoantibody phenotypes of the juvenile idiopathic inflammatory myopathies.
Lisa G. Rider,Mona Shah,Gulnara Mamyrova,Adam M. Huber,Madeline Murguia Rice,Ira N. Targoff,Frederick W. Miller +6 more
TL;DR: It is concluded that juvenile myositis is a heterogeneous group of illnesses with distinct autoantibody phenotypes defined by varying clinical and demographic characteristics, laboratory features, and outcomes.
References
More filters
Journal ArticleDOI
Polymyositis and dermatomyositis (first of two parts)
Anthony Bohan,James B. Peter +1 more
TL;DR: (First of Two Parts)
Journal ArticleDOI
Polymyositis and dermatomyositis (second of two parts).
Anthony Bohan,James B. Peter +1 more
Book
Polymyositis and Dermatomyositis
TL;DR: Early initiation of therapy is essential, since both polymyositis and dermatomyositis respond to immunotherapeutic agents and new immunomodulatory agents currently being tested in controlled trials may prove promising for difficult cases.
Journal ArticleDOI
Frequency of specific cancer types in dermatomyositis and polymyositis: a population-based study.
Christopher Hill,Yuqing Zhang,Bardur Sigurgeirsson,Eero Pukkala,Lene Mellemkjær,Antti Airio,Stephen R. Evans,David T. Felson +7 more
TL;DR: Evidence is provided that dermatomyositis is strongly associated with a wide range of cancers, and the overall risk of malignant disease is modestly increased among patients with polymyositis, with an excess for some cancers.
Journal ArticleDOI
TRIM family proteins and their emerging roles in innate immunity
TL;DR: Recent data are described that reveal broader antiviral and antimicrobial activities of TRIM proteins and their involvement in the regulation of pathogen-recognition and transcriptional pathways in host defence is discussed.