F
Fumihiko Urano
Researcher at Washington University in St. Louis
Publications - 149
Citations - 18195
Fumihiko Urano is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Unfolded protein response & Endoplasmic reticulum. The author has an hindex of 48, co-authored 133 publications receiving 16108 citations. Previous affiliations of Fumihiko Urano include University of Massachusetts Boston & University of Massachusetts Amherst.
Papers
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Journal ArticleDOI
Production of BBF2H7‐derived small peptide fragments via endoplasmic reticulum stress‐dependent regulated intramembrane proteolysis
Koji Matsuhisa,Atsushi Saito,Longjie Cai,Masayuki Kaneko,Takumi Okamoto,Fumika Sakaue,Rie Asada,Rie Asada,Fumihiko Urano,Kanta Yanagida,Masayasu Okochi,Yukitsuka Kudo,Masaki Matsumoto,Keiichi I. Nakayama,Kazunori Imaizumi +14 more
TL;DR: It is demonstrated that S1P cleaves BBF2H7 just before the RXXL S 1P recognition motif, and S2P cut at least three different sites in the membrane (next to Leu380, Met381, and Leu385), indicating that S2 P cleaves the substrates at variable sites or via a multistep process.
Patent
Methods for treating endoplasmic reticulum (er) stress disorders
TL;DR: In this paper, the authors present methods for treating ER stress disorders and for identifying compounds for treating stress disorders, which can be used to diagnose and treat ER stress disorder in patients.
Journal ArticleDOI
Squamous metaplasia in the cyst epithelium of type 1 congenital pulmonary airway malformation after thoracoamniotic shunt placement.
Kentaro Matsuoka,Satoshi Hayashi,Fumihiko Urano,Lihua Julie Zhu,Hajime Okita,Haruhiko Sago,Atsuko Nakazawa +6 more
TL;DR: The results reveal that long-term exposure to the intrauterine environment could possibly lead to the change in the nature of cyst epithelium and consequent squamous metaplasia.
Journal ArticleDOI
Two Cases of Wolfram Syndrome Who Were Initially Diagnosed With Type 1 Diabetes
TL;DR: In this paper , the authors describe two genetically confirmed cases of Wolfram syndrome, a rare endoplasmic reticulum disorder characterized by insulin-dependent diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration.
Posted ContentDOI
A Phase 1b/2a Clinical Trial of Dantrolene Sodium in Patients with Wolfram Syndrome
Damien Abreu,Stephen I. Stone,Toni S. Pearson,Robert C. Bucelli,Ashley N Simpson,Stacy Hurst,Cris M. Brown,Kelly Kries,Hongjie Gu,James Hoekel,Lawrence Tychsen,Gregory P. Van Stavern,Neil H. White,Bess A. Marshall,Tamara Hershey,Fumihiko Urano +15 more
TL;DR: A select few patients seemed to have improvements in beta-cell function, which might correlate with a positive trend in other outcome measures, including visual acuity and neurological functions, which justifies further investigation into using dantrolene sodium and other small molecules targeting the endoplasmic reticulum for the treatment of Wolfram syndrome.