F
Fumihiko Urano
Researcher at Washington University in St. Louis
Publications - 149
Citations - 18195
Fumihiko Urano is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Unfolded protein response & Endoplasmic reticulum. The author has an hindex of 48, co-authored 133 publications receiving 16108 citations. Previous affiliations of Fumihiko Urano include University of Massachusetts Boston & University of Massachusetts Amherst.
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Journal ArticleDOI
Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway
Haiyan Liu,Ali Javaheri,Rebecca J. Godar,John T. Murphy,Xiucui Ma,Nidhi Rohatgi,Jana Mahadevan,Krzysztof L. Hyrc,Paul Saftig,Connie A. Marshall,Michael L. McDaniel,Maria S. Remedi,Babak Razani,Fumihiko Urano,Abhinav Diwan +14 more
TL;DR: Data show that despite continued high-fat intake, intermittent fasting restores autophagic flux in islets and improves glucose tolerance by enhancing glucose-stimulated insulin secretion, beta cell survival, and nuclear expression of NEUROG3, a marker of pancreatic regeneration.
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The IRE1α–XBP1 pathway is essential for osteoblast differentiation through promoting transcription of Osterix
Takahide Tohmonda,Yoshiteru Miyauchi,Rajarshi Ghosh,Masaki Yoda,Shinichi Uchikawa,Jiro Takito,Hideo Morioka,Masaya Nakamura,Takao Iwawaki,Kazuhiro Chiba,Yoshiaki Toyama,Fumihiko Urano,Keisuke Horiuchi +12 more
TL;DR: It is shown that one of the most crucial UPR mediators, inositol‐requiring protein 1α (IRE1α), and its target transcription factor X‐box binding protein 1 (XBP1), are essential for bone morphogenic protein 2‐induced osteoblast differentiation.
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Gene-edited human stem cell–derived β cells from a patient with monogenic diabetes reverse preexisting diabetes in mice
Kristina G. Maxwell,Punn Augsornworawat,Leonardo Velazco-Cruz,Michelle H. Kim,Rie Asada,Nathaniel J. Hogrebe,Shuntaro Morikawa,Fumihiko Urano,Jeffrey R. Millman +8 more
TL;DR: CRISPR-Cas9 correction of a diabetes-inducing gene variant allows for robust differentiation of autologous SC-β cells that can reverse severe diabetes in an animal model.
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Autosomal Dominant Diabetes Arising From a Wolfram Syndrome 1 Mutation
Lori L. Bonnycastle,Peter S. Chines,Takashi Hara,Jeroen R. Huyghe,Amy J. Swift,Pirkko Heikinheimo,Jana Mahadevan,Sirkku Peltonen,Hanna Huopio,Pirjo Nuutila,Pirjo Nuutila,Narisu Narisu,Rachel L. Goldfeder,Michael L. Stitzel,Simin Lu,Michael Boehnke,Fumihiko Urano,Francis S. Collins,Markku Laakso +18 more
TL;DR: A novel nonsynonymous variant (p.Trp314Arg) in the Wolfram syndrome 1 (WFS1) gene is uncovered that segregates completely with the diabetic phenotype and represents the first compelling report of a mutation in WFS1 associated with dominantly inherited nonsyndromic adult-onset diabetes.
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Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells.
Anthony N. Vomund,Bernd H. Zinselmeyer,Jing W. Hughes,Boris Calderon,Carolina Valderrama,Stephen T. Ferris,Xiaoxiao Wan,Kohsuke Kanekura,Javier A. Carrero,Fumihiko Urano,Emil R. Unanue +10 more
TL;DR: It is documents that beta cells from islets of Langerhans normally transfer some of their secretory granules to resident phagocytes, and a process whereby the contents of secretorygranules become available to the immune system.