F
Fumihiko Urano
Researcher at Washington University in St. Louis
Publications - 149
Citations - 18195
Fumihiko Urano is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Unfolded protein response & Endoplasmic reticulum. The author has an hindex of 48, co-authored 133 publications receiving 16108 citations. Previous affiliations of Fumihiko Urano include University of Massachusetts Boston & University of Massachusetts Amherst.
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Journal ArticleDOI
Lack of matrix metalloproteinase (MMP)-1 and -3 expression in Ewing sarcoma may be due to loss of accessibility of the MMP regulatory element to the specific fusion protein in vivo.
Hiroki Yabe,Mariko Fukuma,Fumihiko Urano,Koichi Yoshida,Shingo Kato,Yoshiaki Toyama,Jun-ichi Hata,Akihiro Umezawa +7 more
TL;DR: It is hypothesized that the Ewing sarcoma-specific chimeric genes also transactivate the MMP genes, contributing to the tumor's invasiveness and propensity for metastasis.
Journal ArticleDOI
Acute myeloid leukemia possessing jumping translocation is related to highly elevated levels of EAT/mcl-1, a Bcl-2 related gene with anti-apoptotic functions
Hajime Okita,Akihiro Umezawa,Mariko Fukuma,Takashi Ando,Fumihiko Urano,Makoto Sano,Yuji Nakata,T Mori,Jun-ichi Hata +8 more
TL;DR: A case of acute myeloid leukemia with t(16;21) and a JT in which the long arm of chromosome 1 distal to q21 is translocated to the terminal region of chromosome 10 is reported.
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A phase Ib/IIa clinical trial of dantrolene sodium in patients with Wolfram syndrome
Damien Abreu,Stephen I. Stone,Toni S. Pearson,Robert C. Bucelli,Ashley N Simpson,Stacy Hurst,Cris M. Brown,Kelly Kries,Chinyere Onwumere,Hongjie Gu,James Hoekel,Lawrence Tychsen,Gregory P. Van Stavern,Neil H. White,Bess A. Marshall,Tamara Hershey,Fumihiko Urano +16 more
TL;DR: It is suggested that dantrolene is safe for use in Wolfram syndrome at the specified doses and support further study of danrolene in a randomized, placebo-controlled trial.
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Diabetes: Targeting endoplasmic reticulum to combat juvenile diabetes.
TL;DR: Two innovative studies support endoplasmic reticulum as an emerging target for combating both autoimmune and heritable forms of this disease.
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Establishment of a system for monitoring endoplasmic reticulum redox state in mammalian cells
TL;DR: The mammalian ER redox-sensing system could be used to study the mechanisms of ERRedox regulation and provide a foundation for an approach to develop novel therapeutic modalities for human diseases related to dysregulated ER homeostasis including diabetes, neurodegeneration, and Wolfram syndrome.