F
Fumio Itoh
Researcher at Sapporo Medical University
Publications - 176
Citations - 6455
Fumio Itoh is an academic researcher from Sapporo Medical University. The author has contributed to research in topics: Cancer & DNA methylation. The author has an hindex of 43, co-authored 166 publications receiving 6260 citations.
Papers
More filters
Journal Article
Aberrant Methylation in Gastric Cancer Associated with the CpG Island Methylator Phenotype
Minoru Toyota,Nita Ahuja,Hiromu Suzuki,Fumio Itoh,Mutsumi Ohe-Toyota,Kohzoh Imai,Stephen B. Baylin,Jean Pierre J. Issa,Jean Pierre J. Issa +8 more
TL;DR: The methylation status of five newly cloned CpG islands was examined in 56 gastric cancers and it is suggested that CIMP may be one of the major pathways that contribute to tumorigenesis in Gastric cancers.
Journal ArticleDOI
p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation.
Mutsuhiro Takekawa,Masaaki Adachi,Atsuko Nakahata,Ichiro Nakayama,Fumio Itoh,Hiroyuki Tsukuda,Yoichi Taya,Kohzoh Imai +7 more
TL;DR: It is reported that a member of the protein phosphatase type 2C family, Wip1, has a role in down‐regulating p38‐p53 signaling during the recovery phase of the damaged cells.
Journal ArticleDOI
Contribution of matrilysin (MMP-7) to the metastatic pathway of human colorectal cancers.
TL;DR: Matrilysin showed a correlation with metastasis in a cohort of 83 colorectal cancer patients and marked metastatic potentiation in human coloreCTal cancer xenografts, indicating that it may play a critical role in the metastatic pathway of colorectoral cancers.
Journal ArticleDOI
Frequent hypermethylation of CpG islands and loss of expression of the 14-3-3 sigma gene in human hepatocellular carcinoma.
Norikazu Iwata,Hiroyuki Yamamoto,Shigeru Sasaki,Fumio Itoh,Hiromu Suzuki,Takefumi Kikuchi,Hiroyuki Kaneto,Shouhei Iku,Itaru Ozeki,Yoshiyasu Karino,Toshihiro Satoh,Joji Toyota,Masaaki Satoh,Takao Endo,Kohzoh Imai +14 more
TL;DR: Hypermethylation and the resulting loss of expression of the 14-3-3 σ gene corresponds to one of the most common abnormalities reported to date in HCC, suggesting their crucial role in the development and/or progression of HCC.
Journal Article
Inactivation of the 14-3-3 σ Gene Is Associated with 5′ CpG Island Hypermethylation in Human Cancers
TL;DR: The findings suggest that 14-3-3sigma is inactivated by aberrant methylation of the 5' region in various human cancers and that it might play an important role in the development of undifferentiated gastric cancers.