S
Shigeru Sasaki
Researcher at Sapporo Medical University
Publications - 60
Citations - 3125
Shigeru Sasaki is an academic researcher from Sapporo Medical University. The author has contributed to research in topics: Cancer & DNA methylation. The author has an hindex of 22, co-authored 60 publications receiving 2982 citations.
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Journal ArticleDOI
Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence.
Akinori Takaoka,Sumio Hayakawa,Hideyuki Yanai,Dagmar Stoiber,Dagmar Stoiber,Hideo Negishi,Hideaki Kikuchi,Shigeru Sasaki,Kohzoh Imai,Tsukasa Shibue,Kenya Honda,Tadatsugu Taniguchi +11 more
TL;DR: It is shown that transcription of the p53 gene is induced by IFN-α/β, accompanied by an increase in p53 protein level, and that p53 is critical for antiviral defence of the host.
Journal ArticleDOI
Frequent hypermethylation of CpG islands and loss of expression of the 14-3-3 sigma gene in human hepatocellular carcinoma.
Norikazu Iwata,Hiroyuki Yamamoto,Shigeru Sasaki,Fumio Itoh,Hiromu Suzuki,Takefumi Kikuchi,Hiroyuki Kaneto,Shouhei Iku,Itaru Ozeki,Yoshiyasu Karino,Toshihiro Satoh,Joji Toyota,Masaaki Satoh,Takao Endo,Kohzoh Imai +14 more
TL;DR: Hypermethylation and the resulting loss of expression of the 14-3-3 σ gene corresponds to one of the most common abnormalities reported to date in HCC, suggesting their crucial role in the development and/or progression of HCC.
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Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer.
Masanori Nojima,Hiromu Suzuki,Minoru Toyota,Minoru Toyota,Yoshiyuki Watanabe,Reo Maruyama,Shigeru Sasaki,Yasushi Sasaki,Hiroaki Mita,Noriko Nishikawa,Koji Yamaguchi,Koichi Hirata,Fumio Itoh,Takashi Tokino,Mitsuru Mori,Kohzoh Imai,Yasuhisa Shinomura +16 more
TL;DR: Analysis of global expression revealed that overexpression of SFRP2 repressed Wnt target genes and induced changes in the expression of numerous genes related to proliferation, growth and apoptosis in GC cells.
Journal ArticleDOI
Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors.
Hironobu Sato,Hiromu Suzuki,Minoru Toyota,Masanori Nojima,Reo Maruyama,Shigeru Sasaki,Hideyasu Takagi,Yohei Sogabe,Yasushi Sasaki,Masashi Idogawa,Tomoko Sonoda,Mitsuru Mori,Kohzoh Imai,Takashi Tokino,Yasuhisa Shinomura +14 more
TL;DR: It is demonstrated that Dickkopfs (Dkks) are frequent targets of epigenetic silencing in gastrointestinal tumors, and that loss of DKKs may facilitate tumorigenesis through beta-catenin/T-cell factor-independent mechanisms.
Journal ArticleDOI
Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Human Pancreatic Adenocarcinomas: Clinicopathologic and Prognostic Significance of Matrilysin Expression
Hiroyuki Yamamoto,Fumio Itoh,Shouhei Iku,Yasushi Adachi,Hiroshi Fukushima,Shigeru Sasaki,Mitsuhiro Mukaiya,Koichi Hirata,Kohzoh Imai +8 more
TL;DR: The results suggest that matrilysin may play a key role in progression of pancreatic carcinoma and thereby contribute to a poor prognosis.