Y
Yuji Hinoda
Researcher at Yamaguchi University
Publications - 293
Citations - 11955
Yuji Hinoda is an academic researcher from Yamaguchi University. The author has contributed to research in topics: Cancer & Antigen. The author has an hindex of 62, co-authored 292 publications receiving 11460 citations. Previous affiliations of Yuji Hinoda include University of California, San Francisco & University of Dundee.
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Journal ArticleDOI
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer
Hiromu Suzuki,Hiromu Suzuki,D. Neil Watkins,Kam Wing Jair,Kornel E. Schuebel,Sanford D. Markowitz,Sanford D. Markowitz,Wei Dong Chen,Theresa P. Pretlow,Bin Yang,Yoshimitsu Akiyama,Manon van Engeland,Minoru Toyota,Takashi Tokino,Yuji Hinoda,Kohzoh Imai,James G. Herman,Stephen B. Baylin +17 more
TL;DR: It is shown that restoration of SFRP function in colorectal cancer cells attenuates WNT signaling even in the presence of downstream mutations, and that the epigenetic loss of SfrP function occurs early in coloresceptic cancer progression and may thus provide constitutive W NT signaling that is required to complement downstream mutations in the evolution of coloreCTal cancer.
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Long noncoding RNA MALAT1 promotes aggressive renal cell carcinoma through Ezh2 and interacts with miR-205.
Hiroshi Hirata,Yuji Hinoda,Varahram Shahryari,Guoren Deng,Koichi Nakajima,Z. Laura Tabatabai,Nobuhisa Ishii,Rajvir Dahiya +7 more
TL;DR: It is found that MALAT1 expression was higher in human RCC tissues, where it was associated with reduced patient survival and its interactions with Ezh2 and miR-205 were investigated.
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Contribution of matrilysin (MMP-7) to the metastatic pathway of human colorectal cancers.
TL;DR: Matrilysin showed a correlation with metastasis in a cohort of 83 colorectal cancer patients and marked metastatic potentiation in human coloreCTal cancer xenografts, indicating that it may play a critical role in the metastatic pathway of colorectoral cancers.
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Detection of circulating intercellular adhesion molecule-1 antigen in malignant diseases.
Masayuki Tsujisaki,K. Imai,H Hirata,Y Hanzawa,J Masuya,T Nakano,T Sugiyama,M Matsui,Yuji Hinoda,Akira Yachi +9 more
TL;DR: The findings suggest that serum ICAM‐1 antigen may be a useful marker to monitor tumor burden in cancer patients.
Journal ArticleDOI
Distinct methylation pattern and microsatellite instability in sporadic gastric cancer.
Hiromu Suzuki,Fumio Itoh,Minoru Toyota,Takefumi Kikuchi,Hideki Kakiuchi,Yuji Hinoda,Kohzoh Imai +6 more
TL;DR: The data showed a significant correlation between hMLH1 methylation and MSI in GC, and suggested that a common mechanism of aberrant de novo methylation can be postulated in these cancers.