G
G. Doug Myers
Researcher at Houston Methodist Hospital
Publications - 4
Citations - 2692
G. Doug Myers is an academic researcher from Houston Methodist Hospital. The author has contributed to research in topics: Cytotoxic T cell & Antigen. The author has an hindex of 4, co-authored 4 publications receiving 2449 citations. Previous affiliations of G. Doug Myers include Center for Cell and Gene Therapy & Baylor College of Medicine.
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Journal ArticleDOI
Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma
Martin Pule,Barbara Savoldo,G. Doug Myers,G. Doug Myers,Claudia Rossig,Heidi V. Russell,Heidi V. Russell,Gianpietro Dotti,Gianpietro Dotti,M. Helen Huls,Enli Liu,Adrian P. Gee,Adrian P. Gee,Zhuyong Mei,Eric Yvon,Heidi L. Weiss,Hao Liu,Cliona M. Rooney,Cliona M. Rooney,Helen E. Heslop,Helen E. Heslop,Malcolm K. Brenner,Malcolm K. Brenner +22 more
TL;DR: It is shown in individuals with neuroblastoma that EBV-specific CTLs expressing a chimeric GD2-specific receptor indeed survive longer than T cells activated by the CD3-specific antibody OKT3 and expressing the same chimeric receptor but lacking virus specificity.
Journal ArticleDOI
Antitumor activity and long-term fate of chimeric antigen receptor–positive T cells in patients with neuroblastoma
Chrystal U. Louis,Chrystal U. Louis,Barbara Savoldo,Barbara Savoldo,Gianpietro Dotti,Gianpietro Dotti,Martin Pule,Eric Yvon,G. Doug Myers,Claudia Rossig,Heidi V. Russell,Oumar Diouf,Oumar Diouf,Enli Liu,Hao Liu,Meng Fen Wu,Adrian P. Gee,Zhuyong Mei,Cliona M. Rooney,Cliona M. Rooney,Helen E. Heslop,Helen E. Heslop,Malcolm K. Brenner,Malcolm K. Brenner +23 more
TL;DR: It is shown that GD2-CAR T cells can induce complete tumor responses in patients with active neuroblastoma; these CAR T cells may have extended, low-level persistence in patients, and such persistence was associated with longer survival.
Journal ArticleDOI
Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals.
Ann M. Leen,G. Doug Myers,Uluhan Sili,M. Helen Huls,Heidi L. Weiss,Kathryn S. Leung,George Carrum,Robert A. Krance,Chung Che Chang,Jeffrey J. Molldrem,Adrian P. Gee,Malcolm K. Brenner,Helen E. Heslop,Cliona M. Rooney,Catherine M. Bollard +14 more
TL;DR: Genetic modification of antigen-presenting cell lines are described to facilitate the production of CD4+ and CD8+ T lymphocytes specific for CMV, EBV and several serotypes of adenovirus from a single cell culture.
Journal ArticleDOI
Comparable outcome of alternative donor and matched sibling donor hematopoietic stem cell transplant for children with acute lymphoblastic leukemia in first or second remission using alemtuzumab in a myeloablative conditioning regimen.
Alana A. Kennedy-Nasser,Catherine M. Bollard,G. Doug Myers,Kathryn Leung,Stephen Gottschalk,Yiqun Zhang,Hao Liu,Helen E. Heslop,Malcolm K. Brenner,Robert A. Krance +9 more
TL;DR: For children undergoing stem cell transplantation (SCT) from alternative donors, alemtuzumab with a myeloablative conditioning regimen resulted in DFS comparable to MSD, which explained the difference in survival.