U
Uluhan Sili
Researcher at Marmara University
Publications - 60
Citations - 2206
Uluhan Sili is an academic researcher from Marmara University. The author has contributed to research in topics: Medicine & Cytotoxic T cell. The author has an hindex of 15, co-authored 44 publications receiving 1803 citations. Previous affiliations of Uluhan Sili include Istanbul University & Baylor College of Medicine.
Papers
More filters
Journal ArticleDOI
Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals.
Ann M. Leen,G. Doug Myers,Uluhan Sili,M. Helen Huls,Heidi L. Weiss,Kathryn S. Leung,George Carrum,Robert A. Krance,Chung Che Chang,Jeffrey J. Molldrem,Adrian P. Gee,Malcolm K. Brenner,Helen E. Heslop,Cliona M. Rooney,Catherine M. Bollard +14 more
TL;DR: Genetic modification of antigen-presenting cell lines are described to facilitate the production of CD4+ and CD8+ T lymphocytes specific for CMV, EBV and several serotypes of adenovirus from a single cell culture.
Journal ArticleDOI
Generating CTLs against the subdominant Epstein-Barr virus LMP1 antigen for the adoptive immunotherapy of EBV-associated malignancies
Stephen Gottschalk,Oliver L. Edwards,Uluhan Sili,M. Helen Huls,Tatiana Goltsova,Alan R. Davis,Helen E. Heslop,Cliona M. Rooney +7 more
TL;DR: DeltaLMP1 expression in DCs is nontoxic and enables the generation of LMP1-specific CTLs for future adoptive immunotherapy protocols for patients with L MP1-positive malignancies such as EBV-positive Hodgkin disease.
Journal ArticleDOI
Accelerated Production of Antigen-specific T Cells for Preclinical and Clinical Applications Using Gas-permeable Rapid Expansion Cultureware (g-rex)
Juan F. Vera,Lara J. Brenner,Lara J. Brenner,Ulrike Gerdemann,Ulrike Gerdemann,Minhtran C. Ngo,Minhtran C. Ngo,Uluhan Sili,Uluhan Sili,Hao Liu,Hao Liu,John R. Wilson,Gianpietro Dotti,Gianpietro Dotti,Helen E. Heslop,Ann M. Leen,Ann M. Leen,Cliona M. Rooney,Cliona M. Rooney +18 more
TL;DR: Novel gas-permeable culture devices with a silicone membrane at the base allowing gas exchange to occur uninhibited by the depth of the medium above are evaluated, which effectively supports the expansion of CTL and actually increases output by up to 20-fold while decreasing the required technician time.
Journal ArticleDOI
Selective depletion of donor alloreactive T cells without loss of antiviral or antileukemic responses
Persis Amrolia,Giada Muccioli-Casadei,Eric Yvon,Helen Huls,Uluhan Sili,Eric D. Wieder,Catherine M. Bollard,Jaroslav Michálek,Victor Ghetie,Helen E. Heslop,Jeffrey J. Molldrem,Cliona M. Rooney,John Schlinder,Ellen S. Vitetta,Malcolm K. Brenner +14 more
TL;DR: It is demonstrated that allodepletion with an anti-CD25 immunotoxin following stimulation with HLA-mismatched host LCLs more consistently depleted in vitro alloreactivity than stimulation with host PBMCs, as assessed in primary mixed lymphocyte reactions (MLRs).
Journal ArticleDOI
Herpes simplex virus encephalitis: Clinical manifestations, diagnosis and outcome in 106 adult patients
TL;DR: Although HSVE fatality regressed considerably with acyclovir treatment, many patients survive with sequelae and the results emphasize the importance of early diagnosis and prompt treatment of HSVE.