G
G.E. Orlandini
Researcher at University of Florence
Publications - 30
Citations - 1156
G.E. Orlandini is an academic researcher from University of Florence. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 13, co-authored 28 publications receiving 1120 citations. Previous affiliations of G.E. Orlandini include University of Hamburg.
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Journal ArticleDOI
Aponecrosis: morphological and biochemical exploration of a syncretic process of cell death sharing apoptosis and necrosis.
Lucia Formigli,Laura Papucci,Alessia Tani,Nicola Schiavone,Alessio Tempestini,G.E. Orlandini,Sergio Capaccioli,S. Zecchi Orlandini +7 more
TL;DR: It is concluded that chemically induced hypoxia produces different types of cell death depending on the intensity of the insult and on the ATP availability of the cell, and that the classic apoptosis and necrosis may represent only two extremes of a continuum of intermediate forms of cell demise.
Journal ArticleDOI
Coenzyme q10 prevents apoptosis by inhibiting mitochondrial depolarization independently of its free radical scavenging property.
Laura Papucci,Nicola Schiavone,Ewa Witort,Martino Donnini,Andrea Lapucci,Alessio Tempestini,Lucia Formigli,Sandra Zecchi-Orlandini,G.E. Orlandini,G. Carella,Rosario Brancato,Sergio Capaccioli +11 more
TL;DR: Evaluated the antiapoptotic effects of CoQ10 in response to apoptotic stimuli, serum starvation, antimycin A, and ceramide, which do not generate free radicals, in comparison to control, free radical-generating UVC irradiation.
Journal ArticleDOI
Paracrine effects of transplanted myoblasts and relaxin on post-infarction heart remodelling.
Lucia Formigli,A. M. Perna,Elisabetta Meacci,Lorenzo Cinci,Martina Margheri,Silvia Nistri,Alessia Tani,Josh D. Silvertown,G.E. Orlandini,Cristina Porciani,Sandra Zecchi-Orlandini,Jeffrey A. Medin,Daniele Bani +12 more
TL;DR: The beneficial effects of myoblast grafting on cardiac function are primarily dependent on the paracrine effects of transplanted cells on extracellular matrix remodelling and vascularization, and the combined treatment with myOBlast transplantation and local RLX production may be helpful in preventing deleterious cardiac remodelling.
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Morphofunctional integration between skeletal myoblasts and adult cardiomyocytes in coculture is favored by direct cell-cell contacts and relaxin treatment.
Lucia Formigli,Fabio Francini,Alessia Tani,Roberta Squecco,Daniele Nosi,Lucia Polidori,Silvia Nistri,Laura Chiappini,Valentina Cesati,Alessandra Pacini,Avio Maria Perna,G.E. Orlandini,Sandra Zecchi Orlandini,Daniele Bani +13 more
TL;DR: It is suggested that myoblasts and cardiomyocytes interact actively through gap junctions and that relaxin potentiates the intercellular coupling, and a potential role for gap junctional communication in favoring the inter cellular exchange of regulatory molecules, including Ca2+, in the modulation of myoblast differentiation is discussed.
Journal ArticleDOI
Osteolytic processes in human radicular cysts: morphological and biochemical results
Lucia Formigli,Sandra Zecchi Orlandini,Paolo Tonelli,Marco Giannelli,M. Martini,Maria Luisa Brandi,Maurizio Bergamini,G.E. Orlandini +7 more
TL;DR: In conclusion, active bone resorption may contribute significantly to the growth of these lesions within the jaws.