Daniele Nosi

TL;DR: The results suggest that misfolded proteinaceous aggregates stimulate generic cellular responses as a result of the exposure of regions of the structure that are buried in the normally folded proteins and support the idea that a higher number of degenerative pathologies than previously known might be considered as protein deposition diseases.

TL;DR: The results indicate that astrocytes and microglia in the hippocampus of aged and LPS-infused rats possibly participate in the clearance of cellular debris associated with programmed cell death.

TL;DR: It is found that in mice with partial sciatic nerve ligation, TRPA1 silencing in nociceptors attenuated mechanical allodynia, without affecting macrophage infiltration and oxidative stress, whereasTRPA1silencing in Schwann cells reduced both allodynian and neuroinflammation.

TL;DR: It is suggested that amyloid fibrils induce abnormal accumulation and overstabilization of raft domains in the cell membrane and provide a reasonable, although not unique, mechanistic and molecular explanation for fibril toxicity.

TL;DR: The results of the present study provide novel experimental evidence on the molecular mechanisms underlying the role of RLX in the field of cardiac fibrosis, and suggest that Notch signaling can down-regulate TGF-β1/Smad3-induced fibroblast-myofibroblast transition.