G
G. J. Bruining
Researcher at Boston Children's Hospital
Publications - 15
Citations - 608
G. J. Bruining is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Antigen & Antibody. The author has an hindex of 12, co-authored 15 publications receiving 601 citations.
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Circulating semicarbazide-sensitive amine oxidase is raised both in Type I (insulin-dependent), in Type II (non-insulin-dependent) diabetes mellitus and even in childhood Type I diabetes at first clinical diagnosis
Frans Boomsma,A. H. Van Den Meiracker,S. Winkel,Henk-Jan Aanstoot,M. R. Batstra,A. J. Man In 'T Veld,G. J. Bruining +6 more
TL;DR: The increase of plasma semicarbazide-sensitive amine oxidase in Type I diabetes is confirmed and extended to Type II diabetes as well as to childhood Type I at first clinical diagnosis and in the long run the increased enzyme activities could also contribute to vascular damage by direct cytotoxic action on endothelial cells, including increased oxidative stress and glycosylation of proteins.
Journal ArticleDOI
T-Cell Reactivity to β-Cell Membrane Antigens Associated With β-Cell Destruction in IDDM
Bart O. Roep,A. A. Kallan,Gaby Duinkerken,Susan D. Arden,John C. Hutton,G. J. Bruining,R. R. P. De Vries +6 more
TL;DR: Results imply that T-cell recognition of insulin-secretory granule antigens is associated with IDDM and in particular with the immune-mediated process of β-cell destruction.
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HLA-DO polymorphism associated with resistance to type I diabetes detected with monoclonal antibodies, isoelectric point differences, and restriction fragment length polymorphism.
G. M. T. Schreuder,Marcel G. J. Tilanus,R. E. Bontrop,G. J. Bruining,Marius J. Giphart,J.J. van Rood,R. R. P. De Vries +6 more
TL;DR: The TA10 allele appears to be a new marker for resistance to type I diabetes, which is independent from the known resistance marker DR2, whereas no association was observed between this DQ beta polymorphism and rheumatoid arthritis.
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Incidence of childhood diabetes in The Netherlands: a decrease from north to south over north-western Europe?
TL;DR: The data support the influence of unknown exogenous factors associated with the clinical onset of childhood diabetes.
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Clinical time-course and characteristics of islet cell cytoplasmatic antibodies in childhood diabetes.
TL;DR: Circulating islet cell antibodies (ICA) were present in high frequency early after diagnosis and decreased in the time course of childhood diabetes mellitus, but most of the IgG subclasses could be detected in ICA, but after a duration of one year IgG1 alone was mainly seen.