M
Marius J. Giphart
Researcher at Leiden University Medical Center
Publications - 118
Citations - 4258
Marius J. Giphart is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Human leukocyte antigen & Haplotype. The author has an hindex of 37, co-authored 118 publications receiving 4180 citations. Previous affiliations of Marius J. Giphart include University of Helsinki & Leiden University.
Papers
More filters
Journal ArticleDOI
Secretion of tumour necrosis factor alpha and lymphotoxin alpha in relation to polymorphisms in the TNF genes and HLA-DR alleles. Relevance for inflammatory bowel disease.
G. Bouma,J. B. A. Crusius,M. Oudkerk Pool,Jeroen J. Kolkman,B. M. E. Von Blomberg,P. J. Kostense,Marius J. Giphart,G. M. Th. Schreuder,S. G. M. Meuwissen,Amado Salvador Peña +9 more
TL;DR: This is the first study to show associations between TNF haplotypes and TNFα and LTα secretion when T‐cell stimulators are used, and will contribute to define disease heterogeneity in IBD and may be of relevance for understanding the pathogenesis of autoimmune diseases.
Journal ArticleDOI
Multiple Genetic Alterations Cause Frequent and Heterogeneous Human Histocompatibility Leukocyte Antigen Class I Loss in Cervical Cancer
TL;DR: Altered HLA class I antigen expression occurs in most cervical cancers, is diverse, and is mainly caused by genetic changes, Combined with widespread tumor heterogeneity, these changes have profound implications for natural immunity and T cell–based immunotherapy in cervical cancer.
Journal ArticleDOI
KIR in Type 1 Diabetes: Disparate Distribution of Activating and Inhibitory Natural Killer Cell Receptors in Patients Versus HLA-Matched Control Subjects
Arno R. van der Slik,Bobby P. C. Koeleman,Willem Verduijn,G. Jan Bruining,Bart O. Roep,Marius J. Giphart +5 more
TL;DR: It is proposed that the genetic imbalance between KIR and their HLA class 1 ligands may enhance the activation of T-cells with a low affinity for pancreatic self-antigens, thereby contributing to the pathogenesis of type 1 diabetes.
Journal ArticleDOI
Biotinylated DRB sequence-specific oligonucleotides. Comparison to serologic HLA-DR typing of organ donors in eurotransplant.
W. Verduyn,Ilias I.N. Doxiadis,Jacqueline D.H. Anholts,J.J.M. Drabbels,Albert Naipal,J. D'Amaro,Guido G. Persijn,Marius J. Giphart,Geziena M.Th. Schreuder,Geziena M.Th. Schreuder +9 more
TL;DR: The results indicate (a) that PCR-biotin-SSO is a reliable technique for DNA-based HLA-DR typing and (b) that H LA-DR serology is still a useful technique when time is limited, such as for cadaveric donor typing.
Journal ArticleDOI
Whole genome association study of rheumatoid arthritis using 27 039 microsatellites
Gen Tamiya,Gen Tamiya,Minori Shinya,Minori Shinya,Tadashi Imanishi,Tomoki Ikuta,Tomoki Ikuta,Satoshi Makino,Koichi Okamoto,Koichi Okamoto,Koichi Okamoto,Koh Furugaki,Koh Furugaki,Koh Furugaki,Toshiko Matsumoto,Shuhei Mano,Satoshi Ando,Yasuyuki Nozaki,Wataru Yukawa,Wataru Yukawa,Ryo Nakashige,Daisuke Yamaguchi,Hideo Ishibashi,Hideo Ishibashi,Manabu Yonekura,Yuu Nakami,Yuu Nakami,Seiken Takayama,Takaho A. Endo,Takuya Saruwatari,Takuya Saruwatari,Masaru Yagura,Yoko Yoshikawa,Kei Fujimoto,Akira Oka,Suenori Chiku,Sammuel E.V. Linsen,Marius J. Giphart,Jerzy K. Kulski,Jerzy K. Kulski,Toru Fukazawa,Hiroshi Hashimoto,Minoru Kimura,Yuuichi Hoshina,Yasuo Suzuki,Tomomitsu Hotta,Joji Mochida,Takatoshi Minezaki,Koichiro Komai,Shunichi Shiozawa,Atsuo Taniguchi,Hisashi Yamanaka,Naoyuki Kamatani,Takashi Gojobori,Seiamak Bahram,Hidetoshi Inoko,Hidetoshi Inoko +56 more
TL;DR: Microsatellite-based genome-wide association analysis complemented by end stage SNP typing provides a new tool for genetic dissection of multifactorial pathologies including common diseases.