G Krumbholz

TL;DR: It is suggested that autoantibody formation in response to citrullinated vimentin directly induces bone loss, providing a link between the adaptive immune system and bone.

TL;DR: The results support the idea that adipokines do not directly influence osteophyte development but the proinflammatory conditions in OA.

TL;DR: This histological classification system of osteoarthritis osteophytes provides a helpful tool for analyzing and monitoring osteophyte development and for characterizing osteophyta types within a single human joint and may therefore contribute to achieve comparable results when analyzing histological findings in osteophyts.

TL;DR: The results confirm the proinflammatory potential of adiponECTin and support the idea that adiponectin influences rheumatoid arthritis bone remodelling through alterations in osteoblast and osteoclast.

TL;DR: The analysed adipocytokines most likely are involved in osteophyte formation at different stages and correspondingly affect cells of cartilage and bone formation to a different extent.