G
G L Waldo
Researcher at University of North Carolina at Chapel Hill
Publications - 35
Citations - 2329
G L Waldo is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Phospholipase C & G protein. The author has an hindex of 23, co-authored 35 publications receiving 2228 citations.
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Characterization of an altered membrane form of the beta-adrenergic receptor produced during agonist-induced desensitization.
TL;DR: Data suggest that incubation of 1321N1 human astrocytoma cells with isoproterenol results in a rapid uncoupling of beta-adrenergic receptors from adenylate cyclase which is followed by a change in the membrane form of the receptor.
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Beta gamma-subunit activation of G-protein-regulated phospholipase C.
TL;DR: The observation of direct effects of free beta gamma-subunit on phospholipase C extend the possibilities for receptor-mediated regulation of this signaling pathway.
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Kinetic Scaffolding Mediated by a Phospholipase C–β and Gq Signaling Complex
G L Waldo,Tiffany K. Ricks,Stephanie N. Hicks,Matthew L. Cheever,Takeharu Kawano,Kazuhito Tsuboi,Xiaoyue Wang,Craig Montell,Tohru Kozasa,Tohru Kozasa,John Sondek,T. Kendall Harden +11 more
TL;DR: A dynamic catch-and-release mechanism used to sharpen spatiotemporal signals mediated by diverse sensory inputs is suggested and dramatically delay signal termination in vitro and in vivo.
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RGS6, RGS7, RGS9, and RGS11 stimulate GTPase activity of Gi family G-proteins with differential selectivity and maximal activity.
TL;DR: This study defined the G-protein α-subunit selectivity of purified Sf9 cell-derived R7 proteins, a subfamily of RGS proteins containing a Gγ-like (GGL) domain that mediates dimeric interaction with Gβ5.
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Catecholamine-induced alteration in sedimentation behavior of membrane bound beta-adrenergic receptors
TL;DR: Incubation of astrocytoma cells with catecholamines results in a decrease in catechlamine-stimulated adenylate cyclase activity and a concomitant alteration in the sedimentation properties of particulate beta-adrenergic receptors.