G
Gabriel D. Victora
Researcher at Rockefeller University
Publications - 101
Citations - 10974
Gabriel D. Victora is an academic researcher from Rockefeller University. The author has contributed to research in topics: Germinal center & Antigen. The author has an hindex of 35, co-authored 84 publications receiving 8830 citations. Previous affiliations of Gabriel D. Victora include Massachusetts Institute of Technology & Universidade Federal de Pelotas.
Papers
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Journal ArticleDOI
TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function.
Liang Zhou,Jared E. Lopes,Jared E. Lopes,Mark M.W. Chong,Ivaylo I. Ivanov,Roy Min,Gabriel D. Victora,Yuelei Shen,Jianguang Du,Jianguang Du,Yuri P. Rubtsov,Alexander Y. Rudensky,Steven F. Ziegler,Steven F. Ziegler,Dan R. Littman +14 more
TL;DR: In this article, the authors demonstrate that, together with pro-inflammatory cytokines, TGF-beta orchestrates T helper cells that produce IL-17 (T(H)17 cells) in a concentration-dependent manner.
Journal ArticleDOI
Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter.
Gabriel D. Victora,Tanja A. Schwickert,David R. Fooksman,Alice O. Kamphorst,Michael Meyer-Hermann,Michael L. Dustin,Michel C. Nussenzweig,Michel C. Nussenzweig +7 more
TL;DR: It is found that B cell division is restricted to the DZ, with a net vector of B cell movement from the D Z to the LZ, and T cell help, and not direct competition for antigen, is the limiting factor in GC selection.
Journal ArticleDOI
In vivo analysis of dendritic cell development and homeostasis
Kang Liu,Gabriel D. Victora,Tanja A. Schwickert,Pierre Guermonprez,Matthew M. Meredith,Kai-Hui Yao,Fei Fan Chu,Gwendalyn J. Randolph,Alexander Y. Rudensky,Alexander Y. Rudensky,Michel C. Nussenzweig +10 more
TL;DR: It is shown that DC development progresses from the macrophage and DC precursor to common DC precursors that give rise to pDCs and classical spleen DCs, but not monocytes, and finally to committed precursor of cDCs (pre-cDCs).
Journal ArticleDOI
Germinal Center B Cell Dynamics
TL;DR: Recent developments in the field of GC biology are discussed, with special emphasis on how GC cellular and clonal dynamics shape antibody affinity and diversity during the immune response.
Journal ArticleDOI
Functional Anatomy of T Cell Activation and Synapse Formation
David R. Fooksman,Santosh Vardhana,Gaia Vasiliver-Shamis,Jan Liese,David A. Blair,Janelle Waite,Catarina Sacristán,Gabriel D. Victora,Alexandra Zanin-Zhorov,Michael L. Dustin +9 more
TL;DR: This review examines the molecular components, geometry, and timing underlying kinapses and synapses underlying T cell activation and function, and integrates recent molecular and physiological data to provide a synthesis and suggest ways forward.