G
Gwendalyn J. Randolph
Researcher at Washington University in St. Louis
Publications - 231
Citations - 41267
Gwendalyn J. Randolph is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Lymphatic system & Inflammation. The author has an hindex of 87, co-authored 213 publications receiving 35334 citations. Previous affiliations of Gwendalyn J. Randolph include Technische Universität München & Cornell University.
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Journal ArticleDOI
Nomenclature of monocytes and dendritic cells in blood.
Loems Ziegler-Heitbrock,Petronela Ancuta,Suzanne M. Crowe,Marc Dalod,Marc Dalod,Veronika Grau,Derek N.J. Hart,Pieter J. M. Leenen,Yong-Jun Liu,G. Gordon MacPherson,Gwendalyn J. Randolph,Juergen E. Scherberich,Juergen Schmitz,Ken Shortman,Silvano Sozzani,Herbert Strobl,Marek Zembala,Jonathan M. Austyn,Manfred B. Lutz +18 more
TL;DR: The present document proposes a nomenclature for monocytes and defines 3 types of monocytes (classical, intermediate, and nonclassical monocytes) and3 types of dendritic cells (plasmacytoid and 2 types of myeloid dendrites) in human and in mouse blood.
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Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
Emmanuel L. Gautier,Tal Shay,Tal Shay,Jennifer Miller,Melanie Greter,Claudia Jakubzick,Stoyan Ivanov,Julie Helft,Andrew Chow,Kutlu G. Elpek,Simon Gordonov,Amin R. Mazloom,Avi Ma'ayan,Wei-Jen Chua,Ted H. Hansen,Shannon J. Turley,Miriam Merad,Gwendalyn J. Randolph +17 more
TL;DR: It is identified how well-characterized surface markers, including MerTK and FcγR1 (CD64), along with a cluster of previously unidentified transcripts, were distinctly and universally associated with mature tissue macrophages and how these transcripts and the proteins they encode facilitated distinguishing macrophage from dendritic cells.
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Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques
Frank Tacke,David Alvarez,Theodore J. Kaplan,Claudia Jakubzick,Rainer Spanbroek,Jaime Llodra,Alexandre Garin,Jianhua Liu,Matthias Mack,Nico van Rooijen,Sergio A. Lira,Andreas J. R. Habenicht,Gwendalyn J. Randolph +12 more
TL;DR: Analyzing mouse monocyte subsets in apoE-deficient mice and tracing their differentiation and chemokine receptor usage as they accumulated within atherosclerotic plaques suggests antagonizing CX3CR1 may be effective therapeutically in ameliorating CCR2(+) monocyte recruitment to plaques without impairing their C CR2-dependent responses to inflammation overall.
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Exploiting lymphatic transport and complement activation in nanoparticle vaccines.
Sai T. Reddy,André J. van der Vlies,Eleonora Simeoni,Veronique Angeli,Veronique Angeli,Gwendalyn J. Randolph,Conlin P. O'Neil,Leslie K. Lee,Melody A. Swartz,Jeffrey A. Hubbell +9 more
TL;DR: In this article, the authors investigate whether nanoparticles can be used as a vaccine platform by targeting lymph node-residing dendritic cells via interstitial flow and activating these cells by in situ complement activation.
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Origin and Functions of Tissue Macrophages
TL;DR: The tools used for identifying the complex origin of tissue macrophages are defined and the relative contributions of tissue niche versus ontological origin to the regulation of macrophage functions during steady state and inflammation are discussed.