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Gabriel Nistor
Researcher at University of California, Irvine
Publications - 59
Citations - 3366
Gabriel Nistor is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Stem cell & Transplantation. The author has an hindex of 19, co-authored 52 publications receiving 3087 citations. Previous affiliations of Gabriel Nistor include University of California.
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Journal ArticleDOI
Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury.
Hans S. Keirstead,Gabriel Nistor,Giovanna M. Bernal,Minodora O. Totoiu,Frank Cloutier,Kelly Sharp,Oswald Steward +6 more
TL;DR: It is shown that transplantation of human embryonic stem cell (hESC)-derived oligodendrocyte progenitor cells (OPCs) into adult rat spinal cord injuries enhances remyelination and promotes improvement of motor function.
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Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation.
TL;DR: This differentiation protocol provides a means of generating human oligodendroglial lineage cells in high purity, for use in studies of lineage development, screening assays of oligodendedrocytes and their progenitors, and treating neurodegenerative diseases and traumatic injuries to the adult CNS.
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Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cell Transplants Improve Recovery after Cervical Spinal Cord Injury
TL;DR: To directly address cervical SCI, a C5 midline contusion injury model was used and the efficacy of a candidate therapeutic for thoracic SCI was assessed and human embryonic stem cell (hESC)‐derived oligodendrocyte progenitor cells (OPCs) were transplanted into this cervical model.
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Histological and Functional Benefit Following Transplantation of Motor Neuron Progenitors to the Injured Rat Spinal Cord
Sharyn L. Rossi,Gabriel Nistor,Tanya J. Wyatt,Hong Zhen Yin,Aleksandra J. Poole,John H. Weiss,Matthew J. Gardener,Sipke Dijkstra,David F. Fischer,Hans S. Keirstead +9 more
TL;DR: These findings underscore the barriers imposed on neuronal differentiation of transplanted cells by the gliogenic nature of the injured spinal cord, and the physiological relevance of transplant-derived neurotrophic support to functional recovery.
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Transplanted hESC-Derived Retina Organoid Sheets Differentiate, Integrate, and Improve Visual Function in Retinal Degenerate Rats
Bryce T McLelland,Bin Lin,Anuradha Mathur,Robert B. Aramant,Biju B. Thomas,Gabriel Nistor,Hans S. Keirstead,Magdalene J. Seiler +7 more
TL;DR: Data demonstrate that the transplantation of sheets dissected from hESC-derived retina organoids is a potential therapeutic method for restoring vision in advanced stages of RD.