G
Gabriela E. Garcia
Researcher at University of Colorado Denver
Publications - 51
Citations - 2958
Gabriela E. Garcia is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Kidney disease & Kidney. The author has an hindex of 23, co-authored 49 publications receiving 2339 citations. Previous affiliations of Gabriela E. Garcia include University of Florida & Neurocrine Biosciences.
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Journal ArticleDOI
In Vivo Inhibition of CC and CX3C Chemokine–induced Leukocyte Infiltration and Attenuation of Glomerulonephritis in Wistar-Kyoto (WKY) Rats by vMIP-II
Shizhong Chen,Kevin Bacon,Li Li,Gabriela E. Garcia,Yiyang Xia,David Lo,Darren A. Thompson,Michael A. Siani,Tadashi Yamamoto,Jeffrey K. Harrison,Lili Feng +10 more
TL;DR: It is reported here that vMIP-II has additional antagonistic activity against CX3CR1, the receptor for fractalkine, the receptors for CC and CXC chemokine receptors.
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Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice
Takuji Ishimoto,Miguel A. Lanaspa,MyPhuong T. Le,Gabriela E. Garcia,Christine P. Diggle,Paul S. MacLean,Matthew R. Jackman,Aruna Asipu,Carlos A. Roncal-Jimenez,Tomoki Kosugi,Christopher J. Rivard,Shoichi Maruyama,Bernardo Rodriguez-Iturbe,Laura G. Sánchez-Lozada,David T. Bonthron,Yuri Y. Sautin,Richard J. Johnson +16 more
TL;DR: By reducing the amount of fructose for metabolism in the liver, fructokinase A protects against fructkinase C-mediated metabolic syndrome, providing insights into the mechanisms by which fructose causes obesity and metabolic syndrome.
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Uric Acid Stimulates Fructokinase and Accelerates Fructose Metabolism in the Development of Fatty Liver
Miguel A. Lanaspa,Laura G. Sánchez-Lozada,Christina Cicerchi,Nanxing Li,Carlos A. Roncal-Jimenez,Takuji Ishimoto,MyPhuong T. Le,Gabriela E. Garcia,Jeffrey Thomas,Christopher J. Rivard,Ana Andres-Hernando,Brandi Hunter,George F. Schreiner,Bernardo Rodriguez-Iturbe,Yuri Y. Sautin,Richard J. Johnson +15 more
TL;DR: It is shown in human hepatocytes that uric acid up-regulates KHK expression thus leading to the amplification of the lipogenic effects of fructose, which markedly blocked fructose-induced triglyceride accumulation in hepatocytes in vitro and in vivo.
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IL-6 and Serum Amyloid A Synergy Mediates Angiotensin II–Induced Muscle Wasting
Liping Zhang,Jie Du,Zhaoyong Hu,Guofeng Han,Patrice Delafontaine,Gabriela E. Garcia,William E. Mitch +6 more
TL;DR: An interorgan response to high levels of AngII is suggested: Hepatic production of IL-6 and SAA increases, and these mediators act synergistically to impair insulin/IGF-1 signaling, which promotes muscle proteolysis.
Journal ArticleDOI
Prevention of crescentic glomerulonephritis by immunoneutralization of the fractalkine receptor CX3CR1: Rapid Communication
Lili Feng,Shizhong Chen,Shizhong Chen,Shizhong Chen,Gabriela E. Garcia,Gabriela E. Garcia,Gabriela E. Garcia,Yiyang Xia,Yiyang Xia,Yiyang Xia,Mike A. Siani,Mike A. Siani,Mike A. Siani,Paulo Botti,Paulo Botti,Paulo Botti,Curtis B. Wilson,Curtis B. Wilson,Curtis B. Wilson,Jeffrey K. Harrison,Jeffrey K. Harrison,Jeffrey K. Harrison,Kevin Bacon,Kevin Bacon,Kevin Bacon +24 more
TL;DR: Fractalkine plays a central role in leukocyte trafficking at the endothelium in the high-flow glomerular circuit and, in turn, implicates CX3CR1 as a prime drug target for therapeutic intervention of endothelia-related inflammatory diseases.