C
Christine P. Diggle
Researcher at University of Leeds
Publications - 39
Citations - 3358
Christine P. Diggle is an academic researcher from University of Leeds. The author has contributed to research in topics: RYR1 & Malignant hyperthermia. The author has an hindex of 24, co-authored 37 publications receiving 2984 citations. Previous affiliations of Christine P. Diggle include University of Texas Southwestern Medical Center & St James's University Hospital.
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Journal ArticleDOI
Correction: Corrigendum: Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome
Miguel A. Lanaspa,Takuji Ishimoto,Nanxing Li,Christina Cicerchi,David J. Orlicky,Philip A. Ruzycki,Christopher J. Rivard,Shinichiro Inaba,Carlos A. Roncal-Jimenez,Elise S. Bales,Christine P. Diggle,Aruna Asipu,J. Mark Petrash,Tomoki Kosugi,Shoichi Maruyama,Laura G. Sánchez-Lozada,James L. McManaman,David T. Bonthron,Yuri Y. Sautin,Richard J. Johnson +19 more
TL;DR: This paper presents a new probabilistic method for estimating the response of the immune system to EMTs to laser-spot assisted, 3D image analysis of EMMARM, which shows clear patterns in the response to laser beams.
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Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy
S. Uppal,S. Uppal,Christine P. Diggle,Ian M. Carr,Colin W. G. Fishwick,Mushtaq Ahmed,Gamal H Ibrahim,Philip S Helliwell,Anna Latos-Bielenska,Simon E. V. Phillips,Alexander F. Markham,Christopher P. Bennett,David T. Bonthron +12 more
TL;DR: These findings not only suggest therapies for PHO, but also imply that clubbing secondary to other pathologies may be prostaglandin mediated, and testing for HPGD mutations and biochemical testing forHPGD deficiency in patients with unexplained clubbing might help to obviate extensive searches for occult pathology.
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High‐fat and high‐sucrose (western) diet induces steatohepatitis that is dependent on fructokinase
Takuji Ishimoto,Miguel A. Lanaspa,Christopher J. Rivard,Carlos A. Roncal-Jimenez,David J. Orlicky,Christina Cicerchi,Rachel H. McMahan,Manal F. Abdelmalek,Hugo R. Rosen,Matthew R. Jackman,Paul S. MacLean,Christine P. Diggle,Aruna Asipu,Shinichiro Inaba,Tomoki Kosugi,Waichi Sato,Shoichi Maruyama,Laura G. Sánchez-Lozada,Yuri Y. Sautin,James O. Hill,David T. Bonthron,Richard J. Johnson +21 more
TL;DR: The protection in fructokinase knockout mice suggests a key role for fructose (from sucrose) in this development of steatohepatitis, and emphasize the important role of fructose in the development of fatty liver and nonalcoholic steato hepatitis.
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Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice
Takuji Ishimoto,Miguel A. Lanaspa,MyPhuong T. Le,Gabriela E. Garcia,Christine P. Diggle,Paul S. MacLean,Matthew R. Jackman,Aruna Asipu,Carlos A. Roncal-Jimenez,Tomoki Kosugi,Christopher J. Rivard,Shoichi Maruyama,Bernardo Rodriguez-Iturbe,Laura G. Sánchez-Lozada,David T. Bonthron,Yuri Y. Sautin,Richard J. Johnson +16 more
TL;DR: By reducing the amount of fructose for metabolism in the liver, fructokinase A protects against fructkinase C-mediated metabolic syndrome, providing insights into the mechanisms by which fructose causes obesity and metabolic syndrome.
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Mutations Causing Familial Biparental Hydatidiform Mole Implicate C6orf221 as a Possible Regulator of Genomic Imprinting in the Human Oocyte
David A. Parry,Clare V. Logan,Bruce E. Hayward,Michael Shires,Hanène Landolsi,Christine P. Diggle,Ian M. Carr,Cécile Rittore,Isabelle Touitou,Laurent Philibert,Rosemary A. Fisher,Masoumeh Fallahian,John Huntriss,Helen M. Picton,Saghira Malik,Graham R. Taylor,Colin A. Johnson,David T. Bonthron,Eamonn Sheridan +18 more
TL;DR: The previously described biological properties of their respective gene families suggest that NLRP7 and C6orf221 may interact as components of an oocyte complex that is directly or indirectly required for determination of epigenetic status on the oocyte genome.