G
Gabriela Tudor
Researcher at Science Applications International Corporation
Publications - 4
Citations - 350
Gabriela Tudor is an academic researcher from Science Applications International Corporation. The author has contributed to research in topics: Cytotoxicity & Apoptosis. The author has an hindex of 4, co-authored 4 publications receiving 342 citations.
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Journal ArticleDOI
Flavopiridol Induces Apoptosis of Normal Lymphoid Cells, Causes Immunosuppression, and Has Potent Antitumor Activity In Vivo Against Human Leukemia and Lymphoma Xenografts
Francisco Arguello,Mark J. Alexander,Judith A. Sterry,Gabriela Tudor,Erik M. Smith,Naina T. Kalavar,John F. Greene,William Koss,C. David Morgan,Sherman F. Stinson,Timothy J. Siford,W. Gregory Alvord,Richard L. Klabansky,Edward A. Sausville +13 more
TL;DR: It is concluded that flavopiridol greatly influences apoptosis in both normal and malignant hematopoietic tissues, and provides compelling evidence for the use of flavopirs in human hematologic malignancies.
Journal ArticleDOI
Cytotoxicity and apoptosis of benzoquinones: redox cycling, cytochrome c release, and BAD protein expression.
TL;DR: The overall markedly increased cytotoxicity of the aziridinylbenzoquinone compounds used in this study is accompanied by apoptosis, which occurs mostly through a cytochrome c-independent pathway.
Journal ArticleDOI
Cytotoxicity of RH1: NAD(P)H:quinone acceptor oxidoreductase (NQO1)-independent oxidative stress and apoptosis induction.
Gabriela Tudor,Mike Alley,Christopher M Nelson,Ruili Huang,David G. Covell,Peter L. Gutierrez,Edward A. Sausville +6 more
TL;DR: The cytotoxicity of RH1 in cell lines selected from the NCI's 60 tumor cell line panel, expressing varying levels of NQO1 activity, is investigated, in agreement with previous data suggesting that, in addition to its activation by N QO1, RH1-induced cytot toxicity might involve alternative pathways for activation of this compound.
Journal ArticleDOI
Automated Process of Q-PCR/Gene Expression
James Cherry,Claudia Stewart,Casey Frankenberger,Kelly Martin,Gabriela Tudor,Garrison A. Owens,Narayan K. Bhat,David J. Munroe +7 more
TL;DR: This procedure utilizes commonly available reagents and pre-packaged “kits” for RNA extraction, first strand cDNA synthesis, Q-PCR, liquid handling, and capillary electrophoresis that are generally applicable to a wide variety of robotic platforms.