Gabriele Floris

TL;DR: How the convergence of clinical reports and behavioral phenotyping in mutant mice has helped frame a complex picture of psychopathological features in MAO-deficient individuals is summarized, posing novel conceptual challenges towards the identification of the endophenotypes shared by autism-spectrum disorder, antisocial behavior and impulse-control problems, as well as their monoaminergic underpinnings.

TL;DR: The results suggest that FIN impairs stress reactivity and reduces behavioral activation and impulsive behavior by altering the function of the hypothalamus–pituitary–adrenal (HPA) axis.

TL;DR: IsoAP, the natural 3β‐epimer of AP that acts as an antagonist to the AP‐binding site within GABAA receptors, dose‐dependently reduced the number of tic‐like behaviours induced by stress in D1CT‐7 mice, and data suggest that this steroid may have therapeutic properties in TS.

TL;DR: In this paper, a targeted selection of over 100 drugs using a recently developed opioid self-administration assay in zebrafish was used to identify potential treatments for Opioid use disorder (OUD).

TL;DR: The evidence on the associations between MAOA genetic variants and psychopathology is reviewed and how this evidence may provide important information on the role of 5-HTergic neurotransmission in a broad range of psychiatric disorders is indicated.