G
Gabriele Fontana
Researcher at Friedrich Miescher Institute for Biomedical Research
Publications - 72
Citations - 1593
Gabriele Fontana is an academic researcher from Friedrich Miescher Institute for Biomedical Research. The author has contributed to research in topics: Camptothecin & Alkyl. The author has an hindex of 20, co-authored 71 publications receiving 1421 citations. Previous affiliations of Gabriele Fontana include ETH Zurich & Stony Brook University.
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Design, synthesis and anticancer activities of stilbene-coumarin hybrid compounds: Identification of novel proapoptotic agents.
Federica Belluti,Gabriele Fontana,Laura Dal Bo,Nives Carenini,Chiara Giommarelli,Franco Zunino +5 more
TL;DR: The present study suggests that the 7-methoxycoumarin nucleus, together with the 3,5-disubstitution pattern of the trans-vinylbenzene moiety, are likely promising structural features to obtain excellent antitumor compounds endowed with a apoptosis-inducing capability.
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Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Roger J. Griffin,Gabriele Fontana,Bernard T. Golding,Sophie Guiard,Ian R. Hardcastle,Justin J. J. Leahy,Niall M. B. Martin,Caroline Richardson,Laurent Rigoreau,Martin Stockley,Graeme C. M. Smith +10 more
TL;DR: These structural classes were identified as novel DNA-PK inhibitors and delineated initial structure-activity relationships against DNA- PK, with only a 2-morpholino or 2-(2'-methyl morpholino) group being tolerated at this position.
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Mechanisms of replication and repair in mitochondrial DNA deletion formation
TL;DR: The role of replication and repair in mtDNA deletion formation as well as nucleic acid motifs such as repeats, secondary structures, and DNA damage associated with deletion formation in the mitochondrial genome are discussed.
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Synthesis and biological evaluation of new taxoids derived from 2-deacetoxytaxinine J.
Maurizio Botta,Silvia Armaroli,Silvia Armaroli,Daniele Castagnolo,Gabriele Fontana,Paula Pera,Ezio Bombardelli +6 more
TL;DR: A small library of 2-deacetoxytaxinine J (DAT-J- 1 derivatives was synthesised and tested in vitro for their reversal activity in human mammary carcinoma MDR cell line MCF7-R and one of the new taxoids showed to be active at 0.1 microM when tested in combination with paclitaxel.
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Development of the First Ultra-Potent “Capsaicinoid” Agonist at Transient Receptor Potential Vanilloid Type 1 (TRPV1) Channels and Its Therapeutic Potential
Giovanni Appendino,Luciano De Petrocellis,Marcello Trevisani,Alberto Minassi,Nives Daddario,Aniello Schiano Moriello,David Gazzieri,Alessia Ligresti,Barbara Campi,Gabriele Fontana,Christian Pinna,Pierangelo Geppetti,Vincenzo Di Marzo +12 more
TL;DR: Phenylacetylrinvanil (PhAR, IDN5890) is the most potent vanillamide ever described with potency comparable with that of resiniferatoxin (EC50, 11 pM).