G
Gaël Yvert
Researcher at École normale supérieure de Lyon
Publications - 52
Citations - 5668
Gaël Yvert is an academic researcher from École normale supérieure de Lyon. The author has contributed to research in topics: Spinocerebellar ataxia & Gene. The author has an hindex of 23, co-authored 52 publications receiving 5450 citations. Previous affiliations of Gaël Yvert include French Institute of Health and Medical Research & Harvard University.
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Journal ArticleDOI
Genetic dissection of transcriptional regulation in budding yeast.
TL;DR: To begin to understand the genetic architecture of natural variation in gene expression, genetic linkage analysis of genomewide expression patterns in a cross between a laboratory strain and a wild strain of Saccharomyces cerevisiae was carried out.
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Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats
Georges Imbert,Frédéric Saudou,Frédéric Saudou,Gaël Yvert,Gaël Yvert,Didier Devys,Didier Devys,Yvon Trottier,Yvon Trottier,Jean-Marie Garnier,Jean-Marie Garnier,Chantal Weber,Chantal Weber,Jean-Louis Mandel,Jean-Louis Mandel,Géraldine Cancel,Géraldine Cancel,Nacer Abbas,Nacer Abbas,Alexandra Durr,Alexandra Durr,Olivier Didierjean,Olivier Didierjean,Giovanni Stevanin,Giovanni Stevanin,Yves Agid,Yves Agid,Alexis Brice,Alexis Brice +28 more
TL;DR: The steep inverse correlation between age of onset and CAG number suggests a higher sensitivity to polyglutamine length than in the other polyglUTamine expansion diseases.
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Cloning of the SCA7 gene reveals a highly unstable CAG repeat expansion
Gilles David,Nacer Abbas,Giovanni Stevanin,Alexandra Durr,Gaël Yvert,Géraldine Cancel,Chantal Weber,Georges Imbert,Frédéric Saudou,Eric Antoniou,Harry A. Drabkin,Robert M. Gemmill,Paola Giunti,Ali Benomar,Nicholas W. Wood,Merle Ruberg,Yves Agid,Jean-Louis Mandel,Alexis Brice +18 more
TL;DR: Gonadal instability in SCA7 is greater than that observed in any of the seven known neuro-degenerative diseases caused by translated CAG repeat expansions, and is markedly associated with paternal transmissions.
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Trans -acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors
Gaël Yvert,Rachel B. Brem,Jacqueline Whittle,Joshua M. Akey,Eric J. Foss,Erin N. Smith,Erin N. Smith,Rachel Mackelprang,Rachel Mackelprang,Leonid Kruglyak +9 more
TL;DR: Analysis of regulatory variation in a cross between laboratory and wild strains of Saccharomyces cerevisiae showed that polymorphisms in GPA1 and AMN1 affect expression of genes involved in pheromone response and daughter cell separation.
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Molecular and Clinical Correlations in Spinocerebellar Ataxia 2: A Study of 32 Families
Géraldine Cancel,Alexandra Durr,Olivier Didierjean,Georges Imbert,Katrin Bürk,Agnès Lézin,Samir Belal,Ali Benomar,Myriem Abada-Bendib,Christophe Vial,João Guimarães,Hervé Chneiweiss,Giovanni Stevanin,Gaël Yvert,Nacer Abbas,Frédéric Saudou,Anne-Sophie Lebre,Mohamed Yahyaoui,Fayçal Hentati,Jean-Claude Vernant,Thomas Klockgether,Jean-Louis Mandel,Yves Agid,Alexis Brice +23 more
TL;DR: The frequency of several clinical signs such as myoclonus, dystonia and myokymia increased with the number of CAG repeats whereas the frequency of others was related to disease duration, and instability was confirmed by the high degree of gonadal mosaicism observed in sperm DNA of one patient.