M
Mohamed Yahyaoui
Researcher at Mohammed V University
Publications - 71
Citations - 2515
Mohamed Yahyaoui is an academic researcher from Mohammed V University. The author has contributed to research in topics: Gene & Locus (genetics). The author has an hindex of 21, co-authored 66 publications receiving 2265 citations. Previous affiliations of Mohamed Yahyaoui include Autonomous University of Barcelona & University of Gabès.
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Journal ArticleDOI
Molecular and Clinical Correlations in Autosomal Dominant Cerebellar Ataxia with Progressive Macular Dystrophy (SCA7)
Gilles David,Alexandra Durr,Giovanni Stevanin,Géraldine Cancel,Nacer Abbas,Ali Benomar,Samir Belal,Anne-Sophie Lebre,Myriem Abada-Bendib,D. Grid,Monica Holmberg,Mohamed Yahyaoui,Fayçal Hentati,T. Chkili,Yves Agid,Alexis Brice +15 more
TL;DR: The mutation was highly unstable during transmission, with a mean increase of 10 +/- 16 CAG repeats, which was significantly greater in paternal than in maternal transmissions, and correlated well with the marked anticipation observed in the families.
Journal ArticleDOI
Molecular and Clinical Correlations in Spinocerebellar Ataxia 2: A Study of 32 Families
Géraldine Cancel,Alexandra Durr,Olivier Didierjean,Georges Imbert,Katrin Bürk,Agnès Lézin,Samir Belal,Ali Benomar,Myriem Abada-Bendib,Christophe Vial,João Guimarães,Hervé Chneiweiss,Giovanni Stevanin,Gaël Yvert,Nacer Abbas,Frédéric Saudou,Anne-Sophie Lebre,Mohamed Yahyaoui,Fayçal Hentati,Jean-Claude Vernant,Thomas Klockgether,Jean-Louis Mandel,Yves Agid,Alexis Brice +23 more
TL;DR: The frequency of several clinical signs such as myoclonus, dystonia and myokymia increased with the number of CAG repeats whereas the frequency of others was related to disease duration, and instability was confirmed by the high degree of gonadal mosaicism observed in sperm DNA of one patient.
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Frequency and phenotypic spectrum of ataxia with oculomotor apraxia 2: a clinical and genetic study in 18 patients.
Isabelle Le Ber,Naima Bouslam,Sophie Rivaud-Péchoux,João Guimarães,Ali Benomar,Céline Chamayou,Cyril Goizet,Maria-Ceu Moreira,Sandra Klur,Mohamed Yahyaoui,Yves Agid,Michel Koenig,Giovanni Stevanin,Alexis Brice,Alexandra Durr +14 more
TL;DR: It is shown for the first time that AOA2 can be found in Europe, North Africa and the West Indies, and its relative frequency represents approximately 8% of non-Friedreich ARCA, which is more frequent than ataxia telangiectasia and ataxIA with oculomotor apraxia type 1 (AOA1), in the authors' series of adult patients.
Journal ArticleDOI
Alteration of fatty-acid-metabolizing enzymes affects mitochondrial form and function in hereditary spastic paraplegia
Christelle Tesson,Magdalena Nawara,Magdalena Nawara,Magdalena Nawara,Mustafa A. Salih,Rodrigue Rossignol,Maha S. Zaki,Mohammed Al Balwi,Rebecca Schüle,Cyril Mignot,Emilie Obre,Ahmed Bouhouche,Filippo M. Santorelli,Christelle M. Durand,Andrés Caballero Oteyza,Khalid H. El-Hachimi,Abdulmajeed Al Drees,Naima Bouslam,Foudil Lamari,Salah A. Elmalik,Mohammad M. Kabiraj,Mohammed Zain Seidahmed,Typhaine Esteves,Typhaine Esteves,Typhaine Esteves,Marion Gaussen,Marion Gaussen,Marion Gaussen,Marie Lorraine Monin,Marie Lorraine Monin,Marie Lorraine Monin,Gabor Gyapay,Doris Lechner,Michael A. Gonzalez,Christel Depienne,Fanny Mochel,Julie Lavie,Ludger Schöls,Didier Lacombe,Mohamed Yahyaoui,Ibrahim Al Abdulkareem,Stephan Züchner,Atsushi Yamashita,Ali Benomar,Cyril Goizet,Alexandra Durr,Joseph G. Gleeson,Frédéric Darios,Frédéric Darios,Frédéric Darios,Alexis Brice,Giovanni Stevanin +51 more
TL;DR: It is demonstrated in human cells that the HSP pathophysiology includes alteration of mitochondrial architecture and bioenergetics with increased oxidative stress and focus attention on lipid metabolism as a critical HSP pathway with a deleterious impact on mitochondrial bioenergetic function.
Journal ArticleDOI
The gene for autosomal dominant cerebellar ataxia with pigmentary macular dystrophy maps to chromosome 3p12-p21.1.
A. Benomar,L. Krols,Giovanni Stevanin,Géraldine Cancel,Eric LeGuern,Gilles David,H. Ouhabi,J. J. Martin,Alexandra Durr,A. Zaim,N. Ravisé,C. Busque,C. Penet,N. Van Regemorter,Jean Weissenbach,Mohamed Yahyaoui,T. Chkili,Yves Agid,C. Van Broeckhoven,Alexis Brice +19 more
TL;DR: The results show that ADCA type II is a genetically homogenous disorder, independent of the heterogeneous group of type I cerebellar ataxias.